Synonym: Zygosporin A
|Related Categories||Actin Inhibitors and Probes, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,|
|biological source||from Zygosporium mansonii|
|assay||≥98% (TLC and HPLC)|
Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P264-P281-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||63-25|
|Safety Statements (Europe)||36/37-45|
|RIDADR||UN 1544 6.1/PG 2|
Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Wang SE, Xiang B, Zent R, et al. Cancer Res. 69(2), 475-82, (2009)
Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms. Shida K Immunology 128(1 Suppl), e858-69, (2009)
Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. Shi F, Yang Y, Kouadir M, et al. J. Neuroimmunol. 260(1-2), 121-5, (2013)
Fucoidan directly regulates the chemotaxis of canine peripheral blood polymorphonuclear cells by activating F-actin polymerization. Kim SH, Kang JH, and Yang MP Vet. Immunol. Immunopathol. 151(1-2), 124-31, (2013)
A confocal-based morphometric analysis shows a functional crosstalk between the actin filament system and microtubules in thrombin-stimulated platelets. Severin S, Gaits-Iacovoni F, Allart S, et al. J. Thromb. Haemost. 11(1), 183-6, (2013)
Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells. Vanoverberghe K, Lehen'kyi V, Thébault S, et al. PLoS ONE 7(9), e45615, (2012)
The mechanical environment in Dupuytren's contracture determines cell contractility and associated MMP-mediated matrix remodeling. Verhoekx JS, Beckett KS, Bisson MA, et al. J. Orthop. Res. 31(2), 328-34, (2013)
Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a cells: involvement of PI3 kinase/Akt signalling pathway. Takenouchi T, Iwamaru Y, Imamura M, et al. Cell Biol. Int. 36(12), 1223-31, (2012)
Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction. Xi Y, Ai T, De Lange E, et al. Circ. Arrhythm. Electrophysiol. 5(5), 1017-26, (2012)
Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Whalen K, Reitzel AM, and Hamdoun A Mol. Biol. Cell 23(18), 3663-72, (2012)
A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu. Monique Barel et al BMC Microbiol. 8, 145, (2008)
Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters. Tsakiridis, T., et al. J. Biol. Chem. 269, 29934-29942, (1994)
Cytochalasin D disruption of actin filaments in 3T3 cells produces an anti-apoptotic response by activating gelatinase A extracellularly and initiating intracellular survival signals. Ailenberg, M. and Silverman, M. Biochim. Biophys. Acta 1593, 249-258, (2003)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?