Synonym: Zygosporin A
|Related Categories||Actin Inhibitors and Probes, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,|
|biological source||from Zygosporium mansonii|
|assay||≥98% (TLC and HPLC)|
Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P264-P281-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||63-25|
|Safety Statements (Europe)||36/37-45|
|RIDADR||UN 1544 6.1/PG 2|
A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu. Monique Barel et al BMC Microbiol. 8, 145, (2008)
Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters. Tsakiridis, T., et al. J. Biol. Chem. 269, 29934-29942, (1994)
Cytochalasin D disruption of actin filaments in 3T3 cells produces an anti-apoptotic response by activating gelatinase A extracellularly and initiating intracellular survival signals. Ailenberg, M. and Silverman, M. Biochim. Biophys. Acta 1593, 249-258, (2003)
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|C2618||Cytochalasin D, Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO, 0.2 μm filtered|
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