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C8273 Sigma

Cytochalasin D

from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

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Synonym: Zygosporin A

Cytochalasin D from Zygosporium mansonii, ≥98% (TLC and HPLC), powder
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Description

Biochem/physiol Actions

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.

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