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C8351 Sigma

Anti-Caspase 10 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Caspases,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:500 using a whole extract of Jurkat human acute T leukemia cells extract
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 59 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CASP10(843)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acid residues 359-372 of human caspase 10a p23/p17 with N-terminal added lysine conjugated to KLH with glutaraldehyde.

General description

Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 is a apoptosis-related cysteine protein. It contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Application

Anti-Caspase 10 antibody was used in Immunohistochemistry, western blot and tissue microarray to study the proteomics for esophageal cancer.

Biochem/physiol Actions

Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis which is induced by a variety of inducers such as TNF-α and Anti-Fas antibody. It is a large- prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. It plays a key role in the NF-κB pathway and NF-κB, a signal transduction factor, plays an important part in the carcinogenesis of esophageal cancer. Overexpression of a caspase 10 increases NF-κB activity. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9.

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