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  • C8352 - Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit

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C8352 Sigma

Anti-CXCR4 (Fusin) (182-196) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Description

Immunogen

synthetic peptide corresponding to amino acids 182-196 of the second extracellular loop of human CXCR4.

General description

Chemokine receptor CXCR-4 also refers as fusin or LESTR is a protein that belongs to G-protein coupled receptor 1 family. It is an essential cofactor for T cell-tropic HIV viruses into CD4+ cells. N-Terminal domain and second extracellular loop of the protein act as a HIV binding sites. Anti-CXCR4 (Fusin) (182-196) antibody can be used to block HIV-1 and HIV-2 fusion and infection of human target cells. Rabbit anti-CXCR4 (Fusin) (182-196) antibody reacts specifically with human CXCR4.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Application

Anti-CXCR4 (Fusin) (182-196) antibody may be used in immunoblotting at a working antibody concentration of 0.5 - 1 μg/ml using human HeLa cell extract. It can also be used in immunohistochemistry.

Other Notes

The antigen (receptor) is also termed fusin, LESTER and HUMSTR.

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