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  • C8354 - Anti-CX3CR-1, N-Terminal antibody produced in rabbit

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C8354 Sigma

Anti-CX3CR-1, N-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology, Antibodies to Chemokine Receptors,
species reactivity   mouse, human, rat
application(s)   immunohistochemistry: 2 μg/mL using human heart tissue
  western blot: 0.5-1 μg/mL using human spleen tissue lysate
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 50 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CX3CR1(1524)
mouse ... Cx3cr1(13051)
rat ... Cx3cr1(171056)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the N-terminal and amino acids 2-21 of human CX3CR1 (V28, CMKBRL1). This sequence differs from mouse and rat by four amino acids.

General description

CX3CR1 is a fractalkaine receptor that regulates chemotaxis and adhesion in white blood cells . Impairment of CX3CR1 function has been associated with defects in hippocampal cognition and neuronal plasticity . Cells expressing CX3CR1 receptors inhibit T-cell proliferation and subsequently prevent intestinal inflammation . Anti-CX3CR-1, N-Terminal antibody is specific for CX3CR1 by immunoblotting using human spleen tissue lysate. The antibody also reacts with mouse and rat CX3CR1.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

Application

Anti-CX3CR-1, N-Terminal antibody is suitable for use in immunoblot (approx. 50kDa), western blot (0.5-1 μg/ml) using human spleen lysate) and immunohistochemistry (~2 μg/mL using human heart tissue).

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RIDADR  NONH for all modes of transport
WGK Germany  2
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