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Combinatorial Chemistry: A Practical Approach

  •  ISBN-10 0-19-963754-7

  •  ISBN-13 978-0-19-963754-6

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publication info   H. Fenniri, ed., Oxford University Press, 2000, 432 pp., soft cover
mfr. no.   Oxford University Press

Description

General description

Being a powerful modern technology, combinatorial chemistry has had implications in many areas of chemistry and biology, and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation, and explains the use of automation and robotics.

Table of Contents

Synthesis of combinatorial libraries using the portioning-mixing
procedure
One-bead-one-compound combinatorial library method
Synthesis and screening of positional scanning synthetic
combinatorial libraries
High throughput combinatorial synthesis of discrete compounds in multimilligram quantities
Positionally addressable parallel synthesis on membrane supports
Resins and anchors for solid phase organic synthesis
Organic reactions on solid support - an overview
Analytical methods in combinatorial chemistry
Multi-component reactions (mcrs) of isocyanides and their chemical libraries
Multi-step solution phase combinatorial synthesis
Experimental techniques in fluorous synthesis
Dendrimer-supported combinatorial chemistry
Automated solution phase synthesis and its application in
combinatorial chemistry
Combinatorial discovery and optimization of electrocatalysts
Combinatorial library synthesis using polymer-supported catalysts
Combinatorial Approaches to chiral catalysts discovery

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