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  • C8497 - Anti-CHN2 (16-30) antibody produced in rabbit

C8497 Sigma

Anti-CHN2 (16-30) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-β-Chimaerin, Anti-ARHGAP3, Anti-BCH, Anti-RHOGAP3



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to G Proteins, Antibodies to G Proteins and Cyclic Nucleotides,
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~54 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CHN2(1124)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 16-30 of human CHN2

General description

α-chimaerin, a GTPase-activating protein gene have two isoforms, α1- and α2-chimaerin. Both the isoforms contain C1 and Rho-GAP domains. But α2 (β) isoform contains an unique N-terminal SH2 domain whereas it is absent in α1. It has a cysteine-rich phorbol ester binding domain. It is expressed in granule cells, specifically in late stage spermatocytes. It has molecular mass of 30-kDa.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-CHN2 (16-30) antibody produced in rabbit is suitable for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

GTPase-activating protein activity of CHN2 is regulated by binding of phospholipid and diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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