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C8503 Sigma

Cholesterol

from sheep wool, ≥92.5% (GC), powder

Synonym: 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholesterol, Cholesterol and Cholesterol Metabolism,
biological source   from sheep wool
InChI Key   HVYWMOMLDIMFJA-DPAQBDIFSA-N
assay   ≥92.5% (GC)
form   powder
bp   360 °C(lit.)
mp   147-149 °C(lit.)
solubility   water: soluble0.00003 g/L at 20 °C
density   1.067 g/mL at 25 °C(lit.)
Gene Information   human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)

Description

Biochem/physiol Actions

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Cholesterol is a lipid makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

Packaging

1, 5 kg in poly drum

25, 100, 500 g in poly bottle

Application

Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
FZ8400000
Protocols & Articles

Articles

Cholesterol Biosynthesis

Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the t...
BioFiles 2007, 2.7, 3.
Keywords: Catalog, Catalysis, Decarboxylations, Metabolic Pathways, Oxidations, PAGE, Phosphorylations, Reductions

Protocols

Enzymatic Assay of Cholesterol Oxidase

To standardize a procedure for the determination of the enzymatic assay of Cholesterol Oxidase.
Keywords: Enzyme activity, Extinction coefficient, Isomerizations

Peer-Reviewed Papers
15

References

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