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  • C8604 - Anti-CCR-5, N-Terminal antibody produced in rabbit

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C8604 Sigma

Anti-CCR-5, N-Terminal antibody produced in rabbit

1 mg/mL, IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokine Receptors, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   ELISA: suitable
  immunohistochemistry: suitable
  western blot: suitable
clone   polyclonal
concentration   1 mg/mL
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CCR5(1234)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the N-terminal amino acids 6-20 of human CCR5.

General description

CCR5 is a chemokine receptor belonging to the super family of seven-transmembrane G-protein coupled receptors that mediates cellular functions of immune response, leukocyte migration, development and angiogenesis. CCR5 is expressed on macrophages and Th1 cells activated on inflammation, osteoclasts and vascular smooth muscle cells. Three CC chemokines, CCL3, 4 and 5 bind efficiently to CCR5, whereas CCL7, 8 and 13 bind less efficiently. The expression of CCR5 protein is most important in resistance to HIV-1 and hepatitis C virus infections and reportedly influences the course and progression of the infection. Anti-CCR5, N-Terminal specifically recognizes N terminal of human CCR5 (C-C chemokine receptor type 5).

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

Application

Anti-CCR5, N-Terminal antibody may be used for western blot at 1 μg/mL and for immunohistochemistry at 2.5 μg/mL.

Price and Availability


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