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C8645 Sigma

Cinoxacin

Synonym: 1-Ethyl-1,4-dihydro-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

  • CAS Number 28657-80-9

  • Empirical Formula (Hill Notation) C12H10N2O5

  • Molecular Weight 262.22

  •  MDL number MFCD00056776

  •  PubChem Substance ID 24278343

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   VDUWPHTZYNWKRN-UHFFFAOYSA-N
form   solid
solubility   1 M NaOH: 50 mg/mL
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria

Description

Application

Cinoxacin was used to study the rat renal organic anion transporter 1 (OAT1). It is used to study fluoroquinolone-resistant Streptococcus pyogenes.

Biochem/physiol Actions

Cinoxacin is a synthetic antimicrobial agent that interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. The mechanism of action of cinoxacin is comparable to nalidixic acid. Cinoxacin is effective against Gram-negative bacteria and is often used to treat urinary tract infections caused by E. coli, Proteus mirabilis, Proteus vulgaris and Klebsiella sp.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8645.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Phenyl
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

LC/MS Analysis of Anti-infectives on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Anti-infectives on Ascentis® Express Biphenyl
Keywords: Cosmetics, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

UHPLC Analysis of Antibiotics/Antimalarials on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antibiotics/Antimalarials on Titan™ C18
Keywords: Antibiotics, Chromatography, Mass spectrometry

UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

Peer-Reviewed Papers
15

References

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