Synonym: 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
|Related Categories||Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Bioactive Small Molecules, Biochemicals and Reagents,|
|density||1.067 g/mL at 25 °C(lit.)|
|solubility||Do you have solubility information on this product that you would like to share?|
human ... POLA1(5422), TOP2A(7153)|
rat ... Ar(24208), Polb(29240)
Major component of all biological membranes; ~25% of total brain lipid is cholesterol.
Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane.4 The major sites of cholesterol synthesis are small intestine and liver.5
1, 5, 25, 100 g in poly bottle
500 mg in poly bottle
Cholesterol monohydrate yields a clear, colorless to faint yellow solution in hot alcohol. It is also soluble in acetone, dioxane, ethyl acetate, benzene, petroleum ether, oils, fats, and in aqueous solutions of bile salts. Solutions should be protected from light.
Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses.1 It was incorporated in animal feed to study the effect of cholesterol-rich diet.2,3
Certificate of Analysis
Certificate of Origin
Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the t...
BioFiles 2007, 2.7, 3.
Keywords: Catalysis, Decarboxylations, Metabolic Pathways, Oxidations, PAGE, Phosphorylations, Reductions
1. The combined CTA1-DD/ISCOM adjuvant vector promotes priming of mucosal and systemic immunity to incorporated antigens by specific targeting of B cells Helgeby A et al J. Immunol. 176, 3697-706, (2006)
2. Effects of 2 or 5 consecutive exercise days on adipocyte area and lipid parameters in Wistar rats Guerra RL et al Lipids Health Dis. 6, doi: 10.1186/1476-511X-6-16, (2007)
3. Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study Cavallini DC et al Lipids Health Dis. 8, doi: 10.1186/1476-511X-8-1, (2009)
4. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Dietschy JM and Turley SD J. Lipid Res. 45, 1375-97, (2004)
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths. Comin MJ J. Med. Chem. 52(10), 3274-83, (2009)
Effects of isoflavone-supplemented soy yogurt on lipid parameters and atherosclerosis development in hypercholesterolemic rabbits: a randomized double-blind study. Cavallini DC Lipids Health Dis. 8, 40, (2009)
Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp. Brackman G, Celen S, Hillaert U, et al. PLoS ONE 6(1), e16084, (2011)
Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. Cook PC, Aynsley SA, Turner JD, et al. PLoS Pathog. 7(3), e1001323, (2011)
[Changes in the content of plasma lipoproteins in persons subjected to diets prepared with sunflower oil alone or mixed with palm olein]. Giacopini de Z MI, Alonso HV, Sánchez J, et al. Invest. Clin. 54(2), 171-9, (2013)
Blood pressure and cholesterol control in hypertensive hypercholesterolemic patients: national health and nutrition examination surveys 1988-2010. Egan BM, Li J, Qanungo S, et al. Circulation 128(1), 29-41, (2013)
Mode specific elastic constants for the gel, liquid-ordered, and liquid-disordered phases of DPPC/DOPC/cholesterol model lipid bilayers. Uline MJ and Szleifer I Faraday Discuss. 161, 177-91; discussion 273-303, (2013)
The effect of cholesterol on the intrinsic rate of lipid flip-flop as measured by sum-frequency vibrational spectroscopy. Liu J, Brown KL, and Conboy JC Faraday Discuss. 161, 45-61; discussion 113-50, (2013)
Low-dose estrogen and drospirenone combination: effects on metabolism and endothelial function in postmenopausal women with metabolic syndrome. De Franciscis P, Mainini G, Labriola D, et al. Clin. Exp. Obstet. Gynecol. 40(2), 233-5, (2013)
Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity. Förtsch C, Hupp S, Ma J, et al. Toxins (Basel.) 3(1), 43-62, (2011)
CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection. Fischer MA, Davies ML, Reider IE, et al. PLoS Pathog. 7(11), e1002374, (2011)
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases. Philippe de Medina et al J. Med. Chem. 52, 7765-77, (2009)
Beil. 6,IV,4000 / Beil. 6,III,2607
FT-IR 1 (2), 1048:B / FT-IR 2 (3), 4220:D / FT-NMR 1 (3), 568:A / IR-Spectra (2), 1048:B / IR-Spectra (2), 1277:H / IR-Spectra (3), 1493:H / NMR-Reference 2 (2), 919:B / RegBook 1 (2), 2855:G / Sax 6, 787 / Sigma FT-IR 1 (1), 1207:D / Structure Index 1, 457:B:5
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