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C8754 Sigma

Thiamine pyrophosphate

≥95%

Synonym: Aneurinepyrophosphoric acid, Cocarboxylase, Thiamine pyrophosphate chloride

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Properties

Related Categories Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Other Cofactors
InChI Key   YXVCLPJQTZXJLH-UHFFFAOYSA-N
assay   ≥95%
solubility   H2O: soluble50 mg/mL, clear to very slightly hazy, colorless
storage temp.   −20°C

Description

Packaging

1, 5, 25, 100 g in poly bottle

Application

Thiamine pyrophosphate from Sigma has been used as a substrate to assay the enzymes in golgi lamellae isolated from rat tissue.

Thiamine pyrophosphate has been used in a study to assess decarboxylation mechanisms in biological systems. Thiamine pyrophosphate has also been used in a study to investigate radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases.

Biochem/physiol Actions

Thiamine pyrophosphate is a coenzyme of transketolase that catalyzes the cleavage of ribulose-5-phosphate; thereby forming D-glyceraldehyde-3-phosphate. This reaction requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde. The enzyme is also capable of decarboxylating hydroxypyruvate in the presence of an ′acceptor aldehyde′.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Pyruvate Transformations

Depending on the environmental conditions, e.g. whether oxygen is present or not, pyruvate, a product of glucose metabolism, can undergo different biotransformations as shown in Figure 2. Under reduc...
BioFiles 2007, 2.6, 10.
Keywords: Anaerobic, Biofiles, Catalysis, Environmental, Metabolism

Related Content

Thiamine in Cell Culture

Importance and uses of thiamine in serum-free eucaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
Keywords: Amino Acid Synthesis, Cell culture, Citric Acid Cycle, Culture media, Decarboxylations, Degradations, Metabolism, Nucleophilic additions, Oxidations, Pentose phosphate pathway, Reductions, Vitamins

Peer-Reviewed Papers
15

References

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Add to Cart

92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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