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  • C8854 - Anti-Caspase 13 (ERICE) antibody produced in rabbit

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C8854 Sigma

Anti-Caspase 13 (ERICE) antibody produced in rabbit

~0.5 mg/mL, IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Caspases,
species reactivity   rat, human, mouse
application(s)   microarray: suitable
  western blot: 0.5-1 μg/mL using total HeLa cell lysate or rat or mouse brain lysates.
clone   polyclonal
concentration   ~0.5 mg/mL
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 43 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CASP13(8628)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 91-105 of human caspase 13.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Application

Anti-Caspase 13 (ERICE) antibody is suitable western blot at a concentration of 0.5-1μg/mL using total HeLa cell lysate or rat or mouse brain lysates. It is also suitable for microarray.

Features and Benefits

Antibody Bioguarantee
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Biochem/physiol Actions

Caspases belongs to ICE (interleukin 1β-converting enzyme) family in almost 13 different form. Caspase-13 (ERICE, evolutionary-related interleukin-1 β converting enzyme) is a recently discovered novel member of the caspase family. It is synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) including one large and one small subunit. It is expressed in a variety of human tissues and cell lines but mainly expressed in peripheral blood lymphocytes, spleen, and placenta. Overexpression of ERICE induces apoptosis of human embryonic kidney cells and breast carcinoma cells. Caspase-13 induces apoptosis. It is activated by caspase-8, which is a key enzyme in death receptor induced apoptosis.

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