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C8912 Sigma

Cocaine free base

Synonym: Ecgonine methyl ester benzoate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   ZPUCINDJVBIVPJ-LJISPDSOSA-N
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
Gene Information   human ... DRD3(1814), KCNH1(3756), KCNH2(3757), SCN10A(6336), SCN11A(11280), SCN5A(6331), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)
mouse ... Slc6a2(20538)
rat ... Chrm1(25229), Slc6a3(24898), Slc6a4(25553)

Description

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1544PSN1 6.1 / PGIII
WGK Germany 
3
RTECS 
YM2800000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

HPLC Analysis of Tetramisole Enantiomers and Related Compounds on Astec® CYCLOBOND® I 2000 DMP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tetramisole Enantiomers and Related Compounds on Astec® CYCLOBOND® I 2000 DMP
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Pharmaceutical, Separation, Solvents

LC/MS Analysis of Illicit Drugs and Metabolites on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Illicit Drugs and Metabolites on Ascentis® Express RP-Amide
Keywords: Chromatography, Forensic, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Separation

Peer-Reviewed Papers
15

References

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