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C8982 Sigma

α-Cyano-4-hydroxycinnamic acid

suitable for MALDI-TOF MS

Synonym: α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Glycan Labeling and Analysis, Glycobiology, Mass Spectrometry,
InChI Key   AFVLVVWMAFSXCK-VMPITWQZSA-N
mp   245-250 °C(lit.)
suitability   suitable for MALDI-TOF MS
analyte suitability   glycans
  peptides
  proteins
storage temp.   room temp

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.

General description

α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.
It is also available as part of our ProteoMass MALDI calibration kits (MS-CAL1 and MS-CAL3).

Legal Information

6538 is a trademark of American Type Culture Collection

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

Protocols & Applications

Methods of glycosylated protein analysis by Mass Spectrometry

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Amplified Detection
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Mass Spectrometry of Glycans

The development of modern mass spectrometry (MS) equipment with high resolution and mass accuracy has led to its use in analyzing glycans for both profiling and structural studies. Unlike the HPLC me...
Glycobiology Analysis Manual, 2nd Edition
Keywords: Applications, Catalysis, Centrifugation, High performance liquid chromatography, Mass spectrometry, Phase transitions, Proteomics, Reductions, Sample preparations, Search, Sequencing, Spectra

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Stable Isotope-labeled MS Internal Standards

What happens when you combine state-of-the-art technology with scientific prowess? Full-length protein standards with the highest purity and isotopic incorporation in the industry. Stable isotope-lab...
Keywords: Atomic absorption spectroscopy, Digestions, Mass spectrometry, Phosphorylations

Peer-Reviewed Papers
15

References

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