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C9012 Sigma

Bis(cyclohexanone)oxaldihydrazone

Synonym: Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)

  • CAS Number 370-81-0

  • Empirical Formula (Hill Notation) C14H22N4O2

  • Molecular Weight 278.35

  •  Beilstein Registry Number 2388004

  •  EC Number 206-729-2

  •  MDL number MFCD00001659

  •  PubChem Substance ID 24893128

  • Popular Documents:  FTIR (PDF)  

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Properties

Related Categories B, Cell Biology, Hematology and Histology, Stains & Dyes, A to Z, Stains and Dyes More...
InChI Key   DSRJIHMZAQEUJV-UHFFFAOYSA-N
mp   210-214 °C(lit.)
storage temp.   2-8°C

Description

Application

• Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
• It has been used to induce demyelination in mice.
• It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.

Biochem/physiol Actions

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RO2520000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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