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C9012 Sigma

Bis(cyclohexanone)oxaldihydrazone

Synonym: Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)

  • CAS Number 370-81-0

  • Empirical Formula (Hill Notation) C14H22N4O2

  • Molecular Weight 278.35

  •  Beilstein Registry Number 2388004

  •  EC Number 206-729-2

  •  MDL number MFCD00001659

  •  PubChem Substance ID 24893128

  • Popular Documents:  FTIR (PDF)  

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Properties

Related Categories B, Cell Biology, Hematology and Histology, Stains & Dyes, A to Z, Stains and Dyes More...
InChI Key   DSRJIHMZAQEUJV-UHFFFAOYSA-N
mp   210-214 °C(lit.)
storage temp.   2-8°C

Description

Application

• Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
• It has been used to induce demyelination in mice.
• It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.

Biochem/physiol Actions

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Price and Availability


Tissue Diagnostics

All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RO2520000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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