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C9229 Sigma

Monoclonal Anti-COX I antibody produced in mouse

clone AS70, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-Cyclooxygenase I

Properties

Related Categories A, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling,
species reactivity   human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   AS70, monoclonal
concentration   1 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PTGS1(5742)
conjugate   unconjugated

Description

Immunogen

recombinant full length human COX I, 599 amino acids.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

Application

Monoclonal Anti-COX I antibody produced in mouse is suitable for ELISA and western blotting. It was used to detect mitochondrial cytochrome c oxidase protein markerin homogenate and lipid droplet fractions isolated from L-cells by western blot analysis.1

Features and Benefits

Antibody Bioguarantee
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Biochem/physiol Actions

COX-I, an isoform of COX enzyme with 599 amino acid residues, catalyzes the conversion of arachinodate to prostaglandin H2. It is expressed mainly in the gut for the production of prostaglandins, which inhibit gastric secretion. It is involved in the regulation of homeostatic functions throughout the body, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function.2,3,4,5 It is a target of NSAID (non-steroidal anti-inflammatory drugs) such as aspirin.6 COX-I can be induced by IL-β and other cytokines in monocytes, macrophages, and other cells as part of the inflammatory response.7

Price and Availability


2015 Sigma-Aldrich Antibody Calendar

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