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  • C9347 - Anti-Chloride Channel-1 (CLC-1) antibody produced in rabbit

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C9347 Sigma

Anti-Chloride Channel-1 (CLC-1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chloride Channels, Antibodies to Ion Channels,
species reactivity   mouse, rat
application(s)   western blot (chemiluminescent): 1:200
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CLCN1(1180)
mouse ... Clcn1(12723)
rat ... Clcn1(25688)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 102-117 of rat or mouse CLC-1. The epitope is identical in mouse and rat and homologous to human and goat.

Physical form

Lyophilized at ~0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and 0.025% sodium azide.

Application

Anti-Chloride Channel-1 (CLC-1) antibody produced in rabbit is suitable for western blotting (chemiluminescent) at a working dilution of 1:200.

Features and Benefits

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Biochem/physiol Actions

The protein encoded by this voltage-gated chloride channel gene is involved in regulating the electric excitability of the skeletal muscle membrane. The channel is a homodimer in which each monomer supports an identical pore carrying three anion-binding sites. Mutation in this gene causes two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen).

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