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C9354 Sigma

Monoclonal Anti-COX II antibody produced in mouse

clone AS66, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-Cyclooxygenase II

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, CO-CP,
species reactivity   human
application(s)   flow cytometry: 1 μg/test
  indirect ELISA: suitable
  microarray: suitable
  western blot: suitable
clone   AS66, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PTGS2(5743)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant full length human COX II, 604 amino acids.

General description

COX-II is an isoform of COX enzyme with 604 amino acid residues that catalyzes the conversion of arachinodate to prostaglandin H2.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

Application

Monoclonal Anti-COX II antibody produced in mouse is suitable for immunoblotting at a working concentration of 1 to 5 μg/mL, indirect ELISA, microarray and flow cytometry at 1 μg/test.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

COX-II is a target of NSAID (non-steroidal anti-inflammatory drugs) such as aspirin. It is induced in migratory cells responding to pro-inflammatory stimuli and is an important mediator of inflammation. The prostaglandins produced by COX-II are responsible for the pain and swelling from inflammation. As this enzyme is involved in the production of inflammatory agents, it is the target of intense research and drug discovery activities. COX-II is expressed in new angiogenic endothelial cells, synoviocytes from rheumatoid arthritis patients. It is also markedly expressed in 85% to 90% of human colorectal adenocarcinomas.

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