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  • C9477 - Anti-Chloride Channel-2 (CLC-2, Clcn2) antibody produced in rabbit

C9477 Sigma

Anti-Chloride Channel-2 (CLC-2, Clcn2) antibody produced in rabbit

affinity isolated antibody, lyophilized powder



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chloride Channels, Antibodies to Ion Channels,
species reactivity   rat
application(s)   western blot (chemiluminescent): 1:200-1:400 using rat membranes and ECL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   rat ... Clcn2(29232)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 888-906 of the rat chloride channel-2 (CLC-2).

Physical form

Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide


Anti-Chloride Channel-2 antibody produced in rabbit is suitable for western blot (chemiluminescent) at a working dilution of 1:200-1:400 using rat membranes and ECL.

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Biochem/physiol Actions

The encoded protein, voltage-gated chloride channel, is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Autosomal-recessive mutations ion this gene cause a leukoencephalopathy that affects brain ion and water homoeostasis. It is characterized by intramyelinic oedema. It is involved in maintaining the volume of trabecular meshwork cells by adjusting the outflow of aqueous solutions and for maintaining the fluid balance. It may be a potential target for the treatment of primary open angle glaucoma.

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WGK Germany  2
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