|Related Categories||3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Enzyme Class Index,|
|activity||≥125 units/mg protein|
|purified by||affinity chromatography|
|foreign activity||carboxypeptidase A ≤1%|
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Protein determined by biuret.
Package size based on protein content
Treated with protease inhibitor, AEBSF, to eliminate serine protease activity.
One unit will hydrolyze 1.0 μmole of hippuryl-
Contains HEPES buffer salts and carbohydrate
Carboxypeptidase B has been used in a study to develop a non-invasive pregnancy assay for use in both captive and wild polar bears. Carboxypeptidase B has been used in a study that identified new potential biomarkers of acute pancreatitis.
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(Type II-PMSF treated), ≥50 units/mg protein, aqueous suspension
50-55 units/mg protein carboxypeptidase B
lyophilized powder, ≥50 units/mg protein
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338-P342 + P311|
|Personal Protective Equipment||Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||36/37/38-42|
|Safety Statements (Europe)||22-24-26-36/37|
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Keywords: Cell culture, Cell disruption, Cell signaling, Diagnostic, Digestions, Drug discovery, Functional genomics, Gene expression, Genomics, Metabolic Pathways, Molecular biology, Neuroscience, Proteomics
Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail. Lippi, G. et al. Clin. Lab. Sci. 49, 18-31, (2012)
Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: differences between mild and severe cases and changes over the first three days. Regnér S, Manjer J, Appelros S, et al. Pancreatology 8(6), 600-7, (2008)
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. Du XY, Zabel BA, Myles T, et al. J. Biol. Chem. 284(2), 751-8, (2009)
Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study. Tregouet DA, Schnabel R, Alessi MC, et al. J. Thromb. Haemost. 7(1), 49-57, (2009)
Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Chatterjee S, Ehrenshaft M, Bhattacharjee S, et al. Free Radic. Biol. Med. 46(4), 454-61, (2009)
High-level secretory expression of human procarboxypeptidase B by Fed-Batch cultivation of Pichia pastoris and its partial characterization. Kim MJ, Kim SH, Lee JH, et al. J. Microbiol. Biotechnol. 18(12), 1938-44, (2008)
Activated protein C-protein C inhibitor complex, activation peptide of carboxypeptidase B and C-reactive protein as predictors of severe acute pancreatitis. Hjalmarsson C, Stenflo J, and Borgström A Pancreatology 9(5), 700-7, (2009)
Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. Chatterjee S, Lardinois O, Bonini MG, et al. J. Immunol. 183(6), 4055-66, (2009)
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. Sharif SA, Du X, Myles T, et al. Arthritis Rheum. 60(10), 2902-12, (2009)
Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy. Oliveira-Cunha M, Byers RJ, and Siriwardena AK Pancreas 39(2), 171-4, (2010)
Overexpression, purification, and characterization of beta-subunit group II chaperonin from hyperthermophilic Aeropyrum pernix K1. Shin EJ, Lee JW, Kim JH, et al. J. Microbiol. Biotechnol. 20(3), 542-9, (2010)
Human pancreas-specific protein disulfide-isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins. Fu XM and Zhu BT Biochem. J. 429(1), 157-69, (2010)
Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media. Luo J, Zhang J, Ren D, et al. Biotechnol. Bioeng. 109(9), 2306-15, (2012)
Peroxisome proliferator-activated receptor-alpha agonists repress expression of thrombin-activatable fibrinolysis inhibitor by decreasing transcript stability. Masuda Y, Saotome D, Takada K, et al. Thromb. Haemost. 108(1), 74-85, (2012)
Development and validation of a rapid capillary zone electrophoresis method for determining charge variants of mAb. Shi Y, Li Z, Qiao Y, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 906, 63-8, (2012)
Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: first insights from steered molecular dynamics simulations. Jitonnom J and Sontag C J. Mol. Graph. Model. 38, 298-303, (2012)
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion. Brodrick JW, Geokas MC, and Largman C Biochim. Biophys. Acta 452(2), 468-81, (1976)
Molecular characterization of the carboxypeptidase B1 of Anopheles stephensi and its evaluation as a target for transmission-blocking vaccines. Raz A, Dinparast Djadid N, and Zakeri S Infect. Immun. 81(6), 2206-16, (2013)
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