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C9603 Sigma

Anti-c-Cbl antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Transcription Factors,
species reactivity   human
application(s)   immunoprecipitation: suitable
  microarray: suitable
  western blot: 1:1,000-1:5,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 120 kDa
shipped in   dry ice
Gene Information   human ... CBL(867)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

Synthetic peptide corresponding to the C-terminal region of human c-Cbl (amino acids 889-906) conjugated to KLH.

General description

The proto-oncogene product c-Cbl (p120cbl) is a 120kD cytoplasmic protein found mainly in hematopoietic cell lines. It is located in the cytoplasm and cytoskeleton and has a crucial role in tyrosine kinase-dependent signaling pathways. It also has a pivotal role in hematopoietic cell kinase (Hck) induced signaling of hematopoietic cells. Anti-c-Cbl antibody can be used in immunoprecipitation for detecting and localizing c-Cbl. Rabbit anti-c-Cbl antibody reacts specifically with c-Cbl (120 kD) from human.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Application

Anti-c-Cbl antibody can be used in western blotting (diluted 1:1,000-1:5,000) to detect c-Cbl. It can also be used in microarray.

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