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C9750 Sigma

β-Carotene

Type I, synthetic, ≥93% (UV), powder

Synonym: β,β-Carotene, Provitamin A

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Properties

Related Categories Antioxidant and Free Radical Scavengers, Biochemicals and Reagents, Cancer Research, Carotenoid, Cell Biology,
biological source   synthetic
InChI Key   OENHQHLEOONYIE-JLTXGRSLSA-N
type   Type I
assay   ≥93% (UV)
form   powder
potency   ~1,600,000 units vitamin A per g
color   dark red
solubility   hexane: soluble1.1 mg/mL
  DMSO: soluble30 μg/mL
storage temp.   −20°C

Description

Packaging

5, 10, 25 g in glass bottle

Packaged in serum vials.

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C9750.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

Supplemental Hazard Statements 
Risk of explosion if heated under confinement.
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
FI0329500
Flash Point(F) 
217.4 °F
Flash Point(C) 
103 °C
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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