Colchicine

Papers

Tubulin structure and biochemistry. Luduena, R.F., et al. Curr. Opin. Cell Biol. 4, 53-57, (1992)

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Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Jordan, A., et al. Med. Res. Rev. 18, 259-296, (1998)

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Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. Andreu, J.M., et al. Biochemistry 37, 8356-8368, (1998)

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Differential effects of colchicine and its B-ring modified analog MTPT on the assembly-independent GTPase activity of purified β-tubulin isoforms from bovine brain. Banerjee, A. Biochem. Biophys. Res. Commun. 231, 698, (1997)

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Cell death, phagocytosis, and neurogenesis in mouse olfactory epithelium and vomeronasal organ after colchicine treatment. Suzuki, Y Ann. N. Y. Acad. Sci. 30, 252-254, (1998)

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Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. DeVincenzo, R., et al. Anticancer Drug Des. 13, 19-33, (1998)

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Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. Ceccatelli, S., et al. Neuroreport 8, 3779-3783, (1997)

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Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. Want, T.H., et al. J. Biol. Chem. 273, 4928-4936, (1998)

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In Vivo Analysis Of MT-based Vesicle Transport By Confocal Reflection Microscopy. Gáspár, I., and Szabad, J. Cell Motil. Cytoskeleton 66, 68-79, (2009)

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Genotoxic, Cytostatic, Antineoplastic And Apoptotic Effects Of Newly Synthesized Antitumour Steroidal Esters. Karapidaki, I., et al. Mol. Cell. 675, 51-9, (2009)

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Electrophysiological And Morphological Characteristics And Synaptic Connectivity Of Tyrosine Hydroxylase-expressing Neurons In Adult Mouse Striatum. Ibáñez-Sandoval, O., et al. J. Neurosci. 30, 6999-7016, (2010)

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Derivation And Characterization Of Haploid Embryonic Stem Cell Cultures In Medaka Fish. Yi, M., et al. Nat. Protoc. 5, 1418-30, (2010)

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In Vitro Genotoxicity Of Rocuronium Bromide In Human Peripheral Lymphocytes. Zan, U., et al. Cytotechnology 63, 239-45, (2011)

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Rapid signal transduction in living cells is a unique feature of mechanotransduction. Sungsoo Na et al Proc. Natl. Acad. Sci. U. S. A. 105, 6626-31, (2008)

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Atomic Force Microscope nanolithography on chromosomes to generate single-cell genetic probes. Sebastiano Di Bucchianico et al J. Nanobiotechnology 9, 27, (2011)

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Synthesis and Pharmacological Evaluation of N-[3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl]methanesulfonamide (LP-261), a Potent Antimitotic Agent R. S. Shetty, et al., J. Med. Chem. 54, 179-200, (2011)

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CHMIS-C: a comprehensive herbal medicine information system for cancer. Xueliang Fang et al J. Med. Chem. 48, 1481-8, (2005)

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Discovery of S-phase arresting agents derived from noscapine. James T Anderson et al J. Med. Chem. 48, 2756-8, (2005)

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Identification of novel and improved antimitotic agents derived from noscapine. James T Anderson et al J. Med. Chem. 48, 7096-8, (2005)

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Tubulin-polymerization inhibitors derived from thalidomide. Shunsuke Inatsuki et al Bioorg. Med. Chem. Lett. 15, 321-5, (2005)

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Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Zsolt Székelyhidi et al Bioorg. Med. Chem. Lett. 15, 3241-6, (2005)

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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Yong-Hua Wang et al Bioorg. Med. Chem. Lett. 15, 4076-84, (2005)

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Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors. Xiaohu Ouyang et al Bioorg. Med. Chem. Lett. 15, 5154-9, (2005)

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New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. Feras Q Alali et al J. Nat. Prod. 68, 173-8, (2005)

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Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. Ruili Huang et al J. Med. Chem. 49, 1964-79, (2006)

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Benzoylphenylurea sulfur analogues with potent antitumor activity. Gurulingappa Hallur et al J. Med. Chem. 49, 2357-60, (2006)

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[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines. Siavosh Mahboobi et al J. Med. Chem. 49, 5769-76, (2006)

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2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. Jang-Yang Chang et al J. Med. Chem. 49, 6412-5, (2006)

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7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. Jang-Yang Chang et al J. Med. Chem. 49, 6656-9, (2006)

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9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Anne Zuse et al J. Med. Chem. 49, 7816-25, (2006)

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Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs. Michael Cifuentes et al Bioorg. Med. Chem. Lett. 16, 2761-4, (2006)

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Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. Tomonori Yanagawa et al Bioorg. Med. Chem. Lett. 16, 4748-51, (2006)

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Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles. Jian-Xin Duan et al J. Med. Chem. 50, 1001-6, (2007)

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Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. Giuseppe La Regina et al J. Med. Chem. 50, 2865-74, (2007)

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Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition. Nan Zhang et al J. Med. Chem. 50, 319-27, (2007)

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Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. Aleem Gangjee et al J. Med. Chem. 50, 3290-301, (2007)

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Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets. Nidhal Ben Amor et al J. Med. Chem. 50, 3937-44, (2007)

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4- and 5-aroylindoles as novel classes of potent antitubulin agents. Liou, J.; et al. J. Med. Chem. 50, 4548, (2007)

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Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. Igor V Magedov et al J. Med. Chem. 50, 5183-92, (2007)

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Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Anne Zuse et al J. Med. Chem. 50, 6059-66, (2007)

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Highly potent triazole-based tubulin polymerization inhibitors. Qiang Zhang et al J. Med. Chem. 50, 749-54, (2007)

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Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis. Igor V Magedov et al Bioorg. Med. Chem. Lett. 17, 3872-6, (2007)

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Synthesis and biological activity of 2,5-diaryl-3-methylpyrimido[4,5-c]quinolin-1(2H)-one derivatives. Kamel Metwally et al Bioorg. Med. Chem. 15, 2434-40, (2007)

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Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site. Jessica S Fortin et al Bioorg. Med. Chem. 15, 4456-69, (2007)

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[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis. Michaela Pojarová et al Bioorg. Med. Chem. 15, 7368-79, (2007)

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New functional assay of P-glycoprotein activity using Hoechst 33342. Henrik Müller et al Bioorg. Med. Chem. 15, 7470-9, (2007)

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BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport. Parmjeet Randhawa et al Antimicrob. Agents Chemother. 51, 4492-4, (2007)

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Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. Sara Hoet et al J. Nat. Prod. 70, 1360-3, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I. Patrizia Diana et al J. Med. Chem. 51, 2387-99, (2008)

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2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents. Yu-Hsiang Lo et al J. Med. Chem. 51, 2682-8, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities. Laurent Keller et al J. Med. Chem. 51, 3414-21, (2008)

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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions. Kemnitzer, W.; et al. J. Med. Chem. 51, 417, (2008)

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Discovery of 4-Amino and 4-Hydroxy-1-aroylindoles as Potent Tubulin Polymerization Inhibitors Liou, J.-P.; et al. J. Med. Chem. 51, 4351, (2008)

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Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. Nilantha Sirisoma et al J. Med. Chem. 51, 4771-9, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy. Ravi Kumar Anchoori et al J. Med. Chem. 51, 5953-7, (2008)

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Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity. Daniele Simoni et al J. Med. Chem. 51, 6211-5, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents. Gadarla Randheer Reddy et al J. Med. Chem. 51, 8163-7, (2008)

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Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation. Jessica S Fortin et al Bioorg. Med. Chem. Lett. 18, 3526-31, (2008)

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Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Matthew D Cullen et al Bioorg. Med. Chem. Lett. 18, 469-73, (2008)

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Synthesis and characterization of BODIPY-labeled colchicine. Leggy A Arnold et al Bioorg. Med. Chem. Lett. 18, 5867-70, (2008)

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Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity. Ashutosh Tripathi et al Bioorg. Med. Chem. 16, 2235-42, (2008)

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Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Hiteshkumar D Jain et al Bioorg. Med. Chem. 16, 4626-51, (2008)

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Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Susanne Vogel et al Bioorg. Med. Chem. 16, 6436-47, (2008)

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Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents. Jessica S Fortin et al Bioorg. Med. Chem. 16, 7277-90, (2008)

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Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression. Jessica S Fortin et al Bioorg. Med. Chem. 16, 7477-88, (2008)

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Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents. Nancy Ty et al Bioorg. Med. Chem. 16, 7494-503, (2008)

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Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications. Peter Nussbaumer et al Bioorg. Med. Chem. 16, 7552-60, (2008)

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Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis. Elizabeth W Chia et al Bioorg. Med. Chem. 16, 9432-42, (2008)

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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Fiona L Henriquez et al Antimicrob. Agents Chemother. 52, 1133-5, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Helge Prinz et al J. Med. Chem. 52, 1284-94, (2009)

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Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. Yan Lu et al J. Med. Chem. 52, 1701-11, (2009)

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Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. Samir Messaoudi et al J. Med. Chem. 52, 4538-42, (2009)

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Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach. Wu, Y.-S.; et al. J. Med. Chem. 52, 4941, (2009)

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Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay. Nilantha Sirisoma et al Bioorg. Med. Chem. Lett. 19, 2710-3, (2009)

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Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group. William Kemnitzer et al Bioorg. Med. Chem. Lett. 19, 3045-9, (2009)

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Novel carbazole and acyl-indole antimitotics. Thomas E Barta et al Bioorg. Med. Chem. Lett. 19, 3078-80, (2009)

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Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. William Kemnitzer et al Bioorg. Med. Chem. Lett. 19, 3536-40, (2009)

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Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents. William Kemnitzer et al Bioorg. Med. Chem. Lett. 19, 4410-5, (2009)

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Design, synthesis and identification of novel colchicine-derived immunosuppressant. Dong-Jo Chang et al Bioorg. Med. Chem. Lett. 19, 4416-20, (2009)

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Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum. Rohan A Davis et al Bioorg. Med. Chem. 17, 1387-92, (2009)

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Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers. Han-Zhong Zhang et al Bioorg. Med. Chem. 17, 2852-8, (2009)

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Insecticidal heterolignans - tubulin polymerization inhibitors with activity against chewing pests J. Frackenpohl, et al. Bioorg. Med. Chem. 17, 4160-4184, (2009)

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Design, synthesis and biological evaluation of novel stilbene-based antitumor agents. Simoni, D.; et al. Bioorg. Med. Chem. 17, 512, (2009)

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Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones. Sylvie Ducki et al Bioorg. Med. Chem. 17, 7711-22, (2009)

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Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1, S1-254, (2009)

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Synthesis and biological evaluation of novel symmetry bis-enediynes. Kuo-Feng Tseng et al Eur. J. Med. Chem. 44, 35-41, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Chih-Ying Nien et al J. Med. Chem. 53, 2309-13, (2010)

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Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents. Wen-Tai Li et al J. Med. Chem. 53, 2409-17, (2010)

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N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines. Jonathan A Stefely et al J. Med. Chem. 53, 3389-95, (2010)

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Phenylcinnamides as novel antimitotic agents. Benjamin J Leslie et al J. Med. Chem. 53, 3964-72, (2010)

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Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. Jianjun Chen et al J. Med. Chem. 53, 7414-27, (2010)

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Syntheses and biological evaluation of ring-C modified colchicine analogs. Baiyuan Yang et al Bioorg. Med. Chem. Lett. 20, 3831-3, (2010)

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Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents. Takashi Kozaka et al Bioorg. Med. Chem. Lett. 20, 4091-4, (2010)

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Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells. Juan Xiong et al Bioorg. Med. Chem. 18, 2964-75, (2010)

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Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents. Yong Qian et al Bioorg. Med. Chem. 18, 4310-6, (2010)

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Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Fatma M Abdel Bar et al Bioorg. Med. Chem. 18, 496-507, (2010)

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Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Emma M V Johansson et al Bioorg. Med. Chem. 18, 6589-97, (2010)

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Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents. Yong Qian et al Bioorg. Med. Chem. 18, 8218-25, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Georg Surkau et al Eur. J. Med. Chem. 45, 3354-64, (2010)

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Holger C Nickel et al Eur. J. Med. Chem. 45, 3420-38, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition. Jyothi Vantikommu et al Eur. J. Med. Chem. 45, 5044-50, (2010)

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Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. Kuo-Hsiung Lee et al J. Nat. Prod. 73, 500-16, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. Kyoko Nakagawa-Goto et al J. Med. Chem. 54, 1244-55, (2011)

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Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors F. Xie, et al., J. Med. Chem. 54, 3200-3205, (2011)

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Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis Magedov, I. V.; et al. J. Med. Chem. 54, 4234, (2011)

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N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Helge Prinz et al J. Med. Chem. 54, 4247-63, (2011)

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Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4. Fortin, S.; et al. J. Med. Chem. 54, 4559, (2011)

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Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. Lu, Y.; et al. J. Med. Chem. 54, 4678, (2011)

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Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. Bernard L Flynn et al J. Med. Chem. 54, 6014-27, (2011)

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Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. M Amarnath Reddy et al J. Med. Chem. 54, 6751-60, (2011)

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Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. Giuseppe La Regina et al J. Med. Chem. 54, 8394-406, (2011)

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5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2. Hsueh-Yun Lee et al J. Med. Chem. 54, 8517-25, (2011)

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Synthesis and characterisation of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features. Nicholas J Wardle et al Bioorg. Med. Chem. Lett. 21, 3346-8, (2011)

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Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. Ban-Feng Ruan et al Bioorg. Med. Chem. 19, 2688-95, (2011)

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Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors. Xudong Luan et al Bioorg. Med. Chem. 19, 3312-9, (2011)

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Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation. Yao-Wu Li et al Bioorg. Med. Chem. 19, 3579-84, (2011)

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Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Helge Prinz et al Bioorg. Med. Chem. 19, 4183-91, (2011)

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Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors. Yunqi Li et al Bioorg. Med. Chem. 19, 4529-35, (2011)

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Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents. Yin Luo et al Bioorg. Med. Chem. 19, 4730-8, (2011)

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Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization. Jianjun Chen et al Bioorg. Med. Chem. 19, 4782-95, (2011)

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Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities. Olga N Zefirova et al Bioorg. Med. Chem. 19, 5529-38, (2011)

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Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole. Yuri Yamazaki et al Bioorg. Med. Chem. 19, 595-602, (2011)

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Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides. Demetrio Raffa et al Eur. J. Med. Chem. 46, 2786-96, (2011)

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Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents. Mei-Jung Lai et al Eur. J. Med. Chem. 46, 3623-9, (2011)

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Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships. Sébastien Fortin et al Eur. J. Med. Chem. 46, 5327-42, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents. Ban-Feng Ruan et al Bioorg. Med. Chem. 20, 1113-21, (2012)

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Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents. Xian-Hui Yang et al Bioorg. Med. Chem. 20, 1181-7, (2012)

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Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents. Yang Hu et al Bioorg. Med. Chem. 20, 903-9, (2012)

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Merck 14,2471

Beil. 14,IV,946

Aldrich MSDS 1, 482:D / Corp MSDS 1 (1), 903:B / FT-IR 1 (2), 361:C / FT-IR 2 (2), 2980:D / FT-NMR 1 (2), 1374:C / IR-Spectra (3), 1072:F / IR-Spectra (2), 938:B / NMR-Reference 2 (2), 340:A / RegBook 1 (2), 2007:C / Sigma FT-IR 1 (2), 403:C / Structure Index 1, 320:D:5