|Related Categories||ATM, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase Inhibitors,|
|solubility||DMSO: >5 mg/mL|
Originally published as a selective ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) kinase inhibitor, which causes reversible reprogramming of cellular lifespan, conferred robust growth to senescent cells that had ceased proliferation.
CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Wang, H., et al. Biochem. Biophys. Res. Commun. 422, 103-108, (2012)
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