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C9983 Sigma

Creatine Kinase BB Fraction human

≥90% (SDS-PAGE), liquid, recombinant, expressed in Pichia pastoris



Related Categories Application Index, Biochemicals and Reagents, Creatine Kinases, Diagnostic and Analytical Enzymes, Enzymes, Inhibitors, and Substrates,
recombinant   expressed in Pichia pastoris
assay   ≥90% (SDS-PAGE)
form   liquid
concentration   ≥1.0 mg/mL
storage temp.   −70°C
Gene Information   human ... CKB(1152)


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Frequently Asked Questions are available for this Product.

General description

Solution in 50% glycerol, Tris buffer with 10 mM Bis-Tris-HCl, 0.5mM DTT, 0.5mM EDTA

Unit Definition

One unit will transfer 1.0 μmole of phosphate from creatine phosphate to ADP per minute at 37 °C (measured at 340 nm as one equimolar amount of NADH produced by coupled reaction).


Human creatine kinase BB fraction has been used to investigate the survival benefit of the late percutaneous coronary intervention in patients after acute myocardial infarction. Human creatine kinase BB fraction has also been used in a study to analyze protein oxidations and resultant loss of function.

Biochem/physiol Actions

The product is used as a control in monitoring levels in cerebrospinal fluid by ELISA. Creatine kinase (CK) BB is a member of the CK gene family and is a cytosolic CK isoform present in the brain. The molecular mass is found to be 35-50 kDa. CKs catalyze the reversible transfer of a phosphoryl group between ATP and creatine. It plays an important role in the regulation of ATP level in neural cells. Therefore, a decrease in CK BB activity is one of the biochemical markers of the CNS cell damage in age-related neurodegenerative diseases such as Alzheimer’s disease, Pick’s disease, and Lewy body dementia.

Price and Availability

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

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