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CKOZFN6770 Sigma

CompoZr® Knockout ZFN Kit

Human CUEDC1 (NM_017949)

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Properties

Related Categories CS-DC, CompoZr Knockout ZFN Kits, Functional Genomics and RNAi, Human CompoZr Knockout ZFN Kits, Molecular Biology More...
NCBI accession no.   NM_017949
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CUEDC1(404093)

Description

General description

CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus. Through the cellular process of Non-Homologous End Joining, this double strand break can result in modification of the DNA sequence and therefore create a functional knockout of the targeted gene. To provide the best chance of creating a functional gene knockout, CompoZr Knockout ZFNs are targeted to the first 2/3 of the coding region for the gene of interest.

Legal Information

All Zinc Finger Nucleases are sold under license from Sangamo Biosciences. For a copy of the Label License provided with purchase of CompoZr ZFNs, please visit the ZFN Label License page.

CompoZr is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

CompoZr Knockout ZFNs are provided as 10 aliquots of mRNA encoding for the ZFNs along with plasmid DNA for both ZFN pairs. Also included in the kit are custom-designed primers, that allow for determination of the rate of mutation and for screening of individual clones that have the desired mutational event, and positive control DNA that has been modified using the CompoZr Knockout ZFN.

Biochem/physiol Actions

The ZFN (zinc finger nuclease) provided in this kit targets the CUEDC1 (CUE domain containing 1) gene. CUEDC1 might be involved in protein trafficking and degradation. Changes in this gene are linked with early stage cervical cancer. It is highly methylated in the placental tissue of preeclampsia patients. CUEDC1 is suggested to control trophoblast invasion by participating in the TGF (transforming growth factor)-β/Smad (mothers against decapentaplegic homolog) signaling pathway.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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CKOZFND6770 CompoZr® Knockout ZFN Kit, ZFN plasmid only, Human CUEDC1 (NM_017949)

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