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CKOZFND9211 Sigma

CompoZr® Knockout ZFN Kit, ZFN plasmid only

Human GDF11 (NM_005811)



Related Categories CompoZr Knockout ZFN Kits, Functional Genomics and RNAi, GAK-GO, Human CompoZr Knockout ZFN, plasmid only, Kits, Molecular Biology More...
NCBI accession no.   NM_005811
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... GDF11(10220)


General description

CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus. Through the cellular process of Non-Homologous End Joining, this double strand break can result in modification of the DNA sequence and therefore create a functional knockout of the targeted gene. To provide the best chance of creating a functional gene knockout, CompoZr Knockout ZFNs are targeted to the first 2/3 of the coding region for the gene of interest.

Legal Information

All Zinc Finger Nucleases are sold under license from Sangamo Biosciences. For a copy of the Label License provided with purchase of CompoZr ZFNs, please visit the ZFN Label License page.

CompoZr is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

CompoZr Knockout ZFNs are provided as two plasmids encoding for the gene specific zinc finger nuclease. Also included in the kit are custom-designed primers, that allow for determination of the rate of mutation and for screening of individual clones that have the desired mutational event, and positive control DNA that has been modified using the CompoZr Knockout ZFN.

Biochem/physiol Actions

The zinc finger nuclease (ZFN) provided in this kit targets the gene encoding bone morphogenetic protein-1 (BMP-11). As implied by their name, bone morphogenetic proteins promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. They also enhance protein degradation and reduce skeletal muscle protein synthesis. BMP-11 may have a role in the development of the nervous system in mice. It acts as a modulator of development and differentiation. In mice, circulating levels of BMP-11 decrease with age.

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Safety Information

Safety Information for this product is unavailable at this time.
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CKOZFN9211 CompoZr® Knockout ZFN Kit, Human GDF11 (NM_005811)

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