|Related Categories||Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cholesterol Metabolism Assay Kits,|
|usage||sufficient for 100 assays (200 μL)|
|sufficient for 30 assays (1 mL)|
|shipped in||dry ice|
|Gene Information||human ... HMGCR(3156)|
Live Chat and Frequently Asked Questions are available for this Product.
The HMG-CoA Reductase Assay Kit is an important tool for the basic research of cholesterol and other relelated metabolic pathways.
The HMGR activity kit is designed for the detection of HMG-CoA reductase activity. A major function of the kit is to screen for various inhibitors and activators of the purified catalytic subunit of the enzyme, HMG-CoA reductase, which may play a crucial role in therapeutics. The assay is based on the spectrophotometric measurement of the decrease in absorbance at 340 nm, which represents the oxidation of NADPH by the catalytic subunit of HMGR in the presence of the substrate HMG-CoA.
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3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is a transmembrane glycoprotein, located on the endoplasmic reticulum.1 This enzyme catalyzes the four-electron reduction of HMG-CoA to coenzyme A and ...
BioFiles 2007, 2.7, 2.
Keywords: Cardiovascular, Catalysis, Clinical, Degradations, Enzyme activity, Inflammation, Metabolic Pathways, Oxidations, Phosphorylations, Reductions
1. Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Koning, A.J., et al. Mol. Biol. Cell 7, 769-789, (1996)
5. HMG-CoA reductase inhibitors: effects on chronic subacute inflammation and onset of atherosclerosis induced by dietary cholesterol. Kleemann, R., and Kooistra, T. Curr. Drug Targets 5, 441-453, (2005)
Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins. JEAN-PIERRE H. PERCHELLET et al Int. J. Mol. Med. 24, 633-43, (2010)
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