Synonym: Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt
|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs,|
|impurities||≤0.5% cyclic AMP and 2′-O-monobutyryl-cyclic AMP|
|≤3% N6-monobutyryl-cyclic AMP|
|solubility||H2O: soluble100 mg/mL|
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
Loses 2′-O-butyryl group at pH 8.5
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Certificate of Analysis
Certificate of Origin
Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin E1 in HTLV-I-infected T cells. Ikeda, K., et al. J. Biol. Chem. 268, 1174, (1993)
Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Imamura, M., Ozawa, E. Proc. Natl. Acad. Sci. U. S. A. 95, 6139, (1998)
Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non-transformed rat vascular smooth muscle cells. Leszczynski, D., et al. Am. J. Pathol. 145, 1265-1270, (1994)
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Hei, Y.J., et al. Mol. Pharmacol. 39, 233, (1991)
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