|Related Categories||AMPA/Kainate Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,|
human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)|
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.
The ion channel family of glutamate receptors (“ionotropic” glutamate receptors or iGluR) comprises three major subtypes based on pharmacology and protein structure.
Keywords: Anticonvulsants, Atomic absorption spectroscopy, Clinical, Gene expression, Ligands, Neurotransmission, Physiological Processes, Schizophrenia
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. Gibson JR J. Neurosci. 29(44), 13883-97, (2009)
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. Xu W, Tse YC, Dobie FA, et al. J. Neurosci. 33(13), 5867-77, (2013)
The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris. Yamada R, Okuda H, Kuba H, et al. J. Neurosci. 33(9), 3927-38, (2013)
Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex. Chen S, Mohajerani MH, Xie Y, et al. J. Neurosci. 32(39), 13510-9, (2012)
Selective activation of group III metabotropic glutamate receptor subtypes produces different patterns of γ-aminobutyric acid immunoreactivity and glutamate release in the retina. Guimarães-Souza EM and Calaza KC J. Neurosci. Res. 90(12), 2349-61, (2012)
The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity. De Jaeger X, Bishop SF, Ahmad T, et al. Psychopharmacology 225(3), 687-95, (2013)
Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices. Lindquist BE and Shuttleworth CW Neuroscience 223, 365-76, (2012)
AMPA/kainate receptors in the ventromedial hypothalamus mediate the effects of glutamate on estrus termination in the rat. Georgescu M, Cyr D, and Pfaus JG Pharmacol. Biochem. Behav. 102(1), 146-50, (2012)
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