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D054 Sigma

R(+)-SCH-23390 hydrochloride

≥98% (HPLC), solid

Synonym: R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

  • CAS Number 125941-87-9

  • Empirical Formula (Hill Notation) C17H18ClNO · HCl

  • Molecular Weight 324.24

  •  MDL number MFCD00069249

  •  PubChem Substance ID 24277910



Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   solid
optical activity   [α]/D +32.1°, c = 1 in DMF(lit.)
storage condition   protect from light
color   white
solubility   H2O: >5 mg/mL
Gene Information   human ... DRD1(1812)


Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist.


5, 10, 25, 100 mg in glass bottle

Legal Information

Sold with the permission of Schering-Plough.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. http://www.sigmaaldrich.com/etc/medialib/docs/Sigma-Aldrich/General_Information/shippingandlong-termstoragev3.Par.0001.File.tmp/shippingandlong-termstoragev3.pdf
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?
The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.
What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?
Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.
Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?
Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.
What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?
The melting point is 247-248°C.
Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?
The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.  Please use the link below to view more information about the receptors:  http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/RBI_Handbook/rbibook5_doparcpt.Par.0001.File.tmp/rbibook5_doparcpt.pdf
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