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  • D0627 - N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

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D0627 Sigma

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

≥96% (HPLC), powder

Synonym: Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents, Cyclic Nucleotide Metabolism,
InChI Key   KRBZRVBLIUDQNG-JBVYASIDSA-M
assay   ≥96% (HPLC)
form   powder
impurities   ≤0.5% Cyclic AMP
  ≤3% monobutyryl derivatives
color   off-white
solubility   H2O: 50 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

Caution

Loses 2′-O-butyryl group at pH 8.5

Packaging

1 g in poly bottle

25, 100, 250 mg in poly bottle

Application

Dibutyryl cAMP is a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway. Dibutyryl cAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. It is used in a variety of neural differentiation studies.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
ES5055500
Protocols & Articles

Articles

Chondroitinase for Neural Regeneration Research

The spinal cord is the information highway system for the brain. And axons are the road that allows information data to be transferred. So, when a traumatic spinal cord injury (SCI) occurs and axons ...
Keywords: Catalysis, Cell culture, Degradations, High performance liquid chromatography, Immunofluorescence, PAGE

Protocols

Neural Stem Cell Culture Protocols

Introduction Methods     Isolation of Neural Stem Cells         Isolation of NSCs from Neural Tissue         Differentiation of Human iPSCs into NSCs         Characterization of Neural Stem Cells    ...
Keywords: AGE, Adhesion, Apoptosis, Cell culture, Central Nervous System, Cryopreservation, Culture media, Diseases, Growth factors, High performance liquid chromatography, Phase transitions, Phosphorylations, Purification

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
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