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  • D0627 - N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

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D0627 Sigma

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

≥96% (HPLC), powder

Synonym: Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents, Cyclic Nucleotide Metabolism,
InChI Key   KRBZRVBLIUDQNG-JBVYASIDSA-M
assay   ≥96% (HPLC)
form   powder
impurities   ≤0.5% Cyclic AMP
  ≤3% monobutyryl derivatives
color   off-white
solubility   H2O: soluble50 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

Caution

Loses 2′-O-butyryl group at pH 8.5

Packaging

1 g in poly bottle

25, 100, 250 mg in poly bottle

Application

Dibutyryl cAMP is a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway. Dibutyryl cAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. It is used in a variety of neural differentiation studies.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
ES5055500
Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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