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D101 Sigma

(±)-DOI hydrochloride

≥98% (HPLC), solid

Synonym: (±)-DOI, (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

  • CAS Number 42203-78-1

  • Empirical Formula (Hill Notation) C11H16INO2 · HCl

  • Molecular Weight 357.62

  •  MDL number MFCD00055199

  •  PubChem Substance ID 24278092

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Properties

Related Categories Agonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators,
InChI Key   QVFDMWGKHUFODK-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
drug control   Home Office Schedule 1regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to off-white
solubility   H2O: 10 mg/mL
  ethanol: 2 mg/mL
Gene Information   human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Packaging

10 mg in glass bottle

25 mg in poly bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

LC/MS (TOF) Analysis of 2C Amines Drugs of Abuse in Urine on Ascentis® Express HILIC after Solid Phase Extraction (SPE) using Supel™-Select SCX

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of 2C Amines Drugs of Abuse in Urine on Ascentis® Express HILIC after Solid Phase Extraction (SPE) using Supel™-Select SCX
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Sample preparations, Solid phase extractions

LC/MS Analysis of 2C Amines Drugs of Abuse on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of 2C Amines Drugs of Abuse on Ascentis® Express HILIC
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry

Peer-Reviewed Papers
15

References

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