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D1064 Sigma

Dihydrokainic acid

≥98% (HPLC), powder

Synonym: 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

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Properties

Related Categories AMPA/Kainate Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   JQPDCKOQOOQUSC-OOZYFLPDSA-N
assay   ≥98% (HPLC)
form   powder
solubility   H2O: >10 mg/mL
storage temp.   2-8°C
Gene Information   human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
rat ... Slc1a2(29482), Slc1a3(29483)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety Information

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NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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