|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, DIG-DY, Enzyme Inhibitors,|
|solubility||H2O: slightly soluble0.17 mg/mL|
45% (w/v) aq 2-hydroxypropyl-β-cyclode|
|0.1 M HCl: slightly soluble|
|aqueous buffer pH > 5: soluble|
|Gene Information||human ... COMT(1312)|
Chelating reagent used in a sensitive (μM) assay for vanadium.1
Selective inhibitor of catechol O-methyl transferase (COMT); penetrates the blood brain barrier and is useful both orally and parenteraly in experiments where inhibition of COMT in the central nervous system is required.
250 mg in poly bottle
50 mg in glass bottle
Solutions may be stored for several days at 4 °C.
While reuptake of catecholamines plays an important role in regulating their synaptic levels, metabolism also contributes significantly to the termination of catecholamine neurotransmission. The rela...
Keywords: Atomic layer deposition, Clinical, Dopamine agents, Metabolism, Metabolites, Neurotransmission, Parkinson Disease
Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate. Okada M, Nakao R, Hosoi R, et al. J. Cereb. Blood Flow Metab. 31(1), 124-31, (2011)
COMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitro. Werner P, Di Rocco A, Prikhojan A, et al. Brain Res. 893(1-2), 278-81, (2001)
Catechol-O-methyltransferase inhibition increases the uptake of 11C-3-(3,4-dihydroxyphenyl)-L-alanine in the rat pancreas. Bergström M, Lu L, Marquez M, et al. Scand. J. Gastroenterol. 31(12), 1216-22, (1996)
Plasma clearances and extractions of four catecholamines in the anesthetized rabbit: the role of amine removal by blood cells. Friedgen B, Halbrügge T, and Graefe KH J. Cardiovasc. Pharmacol. 21(1), 21-8, (1993)
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