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D138 Sigma

5,7-Dichlorokynurenic acid monohydrate

solid, ≥98% (HPLC)

Synonym: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid monohydrate

  • CAS Number 190908-40-8

  • Empirical Formula (Hill Notation) C10H5Cl2NO3 · H2O

  • Molecular Weight 276.07

  •  MDL number MFCD11045951

  •  PubChem Substance ID 24277976

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, Ion Channels, Ionotropic Glutamate Receptor Modulators,
InChI Key   READYYZXDSXRQJ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   light yellow
solubility   DMSO: >10 mg/mL
  H2O: insoluble
Gene Information   human ... GRIN1(2902), NGFR(4804)
mouse ... Gria1(14799), Grin2a(14811)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Grin2b(24410)

Description

Biochem/physiol Actions

Potent excitatory amino acid receptor antagonist; active at the strychnine-insensitive glycine binding site of the NMDA glutamate receptor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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