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D138 Sigma

5,7-Dichlorokynurenic acid monohydrate

solid, ≥98% (HPLC)

Synonym: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid monohydrate

  • CAS Number 190908-40-8

  • Empirical Formula (Hill Notation) C10H5Cl2NO3 · H2O

  • Molecular Weight 276.07

  •  MDL number MFCD11045951

  •  PubChem Substance ID 24277976

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, Ion Channels, Ionotropic Glutamate Receptor Modulators,
InChI Key   READYYZXDSXRQJ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   light yellow
solubility   DMSO: >10 mg/mL
  H2O: insoluble
Gene Information   human ... GRIN1(2902), NGFR(4804)
mouse ... Gria1(14799), Grin2a(14811)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Grin2b(24410)

Description

Biochem/physiol Actions

Potent excitatory amino acid receptor antagonist; active at the strychnine-insensitive glycine binding site of the NMDA glutamate receptor.

Packaging

25, 100, 250 mg in poly bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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