• USA Home
  • D1515 - Doxorubicin hydrochloride

EMAIL THIS PAGE TO A FRIEND
D1515 Sigma

Doxorubicin hydrochloride

98.0-102.0% (HPLC)

Synonym: DOX, Hydroxydaunorubicin hydrochloride

Purchase

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

10 mg in glass bottle

Biochem/physiol Actions

Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QI9295900
Protocols & Articles

Articles

ABC Transporters and Cancer Drug Resistance

Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Search, Transfection, Vectors

Applications of Graphene Oxide and Reduced Graphene Oxide

Graphene oxide (GO, Aldrich product numbers 763705 and 777676) is a unique material that can be viewed as a single monomolecular layer of graphite with various oxygen containing functionalities such ...
Avery Luedtke, Ph.D.
Aldrich Materials Science, Sigma-Aldrich Co. LLC
Keywords: Cancer, Catalysis, Materials Science, Nanomaterials, Reductions, Semiconductor, Solar cells

Determination of Water Content in Doxorubicin hydrochloride Using Karl Fischer Titration

The substance exhibited varying dissolution behavior. It only dissolved satisfactorily in methanol with formamide added as a solubilizer. Approx. 0.3 g dissolved in HYDRANAL-Solvent, larger sample qu...
Keywords: Pharmaceutical, Titrations

Inhibition of Nucleic Acid Synthesis by Antibiotics

Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication. DNA gyra...
BioFiles 2006, 1.4, 7.
Keywords: Antibiotics, Antitumor agents, Cancer, DNA replication

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?