D1515 Sigma

Doxorubicin hydrochloride

98.0-102.0% (HPLC)

Synonym: DOX, Hydroxydaunorubicin hydrochloride

Description

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Biochem/physiol Actions

Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;1 Properties.2,3

Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.

Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.

Packaging

10 mg in glass bottle

Legal Information

Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

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