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D1530 Sigma

1α,25-Dihydroxyvitamin D3

≥99% (HPLC)

Synonym: 1α,25-Dihydroxycholecalciferol, Calcitriol

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Properties

Related Categories Cell Biology, Nutrition Research, Vitamin D, Vitamin D3, Vitamins More...
Quality Level   PREMIUM
InChI Key   GMRQFYUYWCNGIN-NKMMMXOESA-N
assay   ≥99% (HPLC)
storage temp.   −20°C
solubility   Do you have solubility information on this product that you would like to share?
Gene Information   human ... VDR(7421)

Description

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Biochem/physiol Actions

Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
FZ4645000
Protocols & Articles

Articles

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniq...
Chloe McClanahan
BioFiles 2009, 4.6, 4.
Keywords: Absorption, Angiogenesis, Biofiles, Biological processes, Cancer, Clinical, Gene expression, Growth factors, Hormones, Hydroxylations, Ligands, Metabolites, Transcription, Type, Vitamins

Peer-Reviewed Papers
15

References

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Product #

Description

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705942 1α,25-Dihydroxyvitamin D3 (6,19,19-d3), 97 atom % D, 96% (CP)
740578 1α,25-Dihydroxyvitamin D3 (6,19,19-d3) solution, 100 μg/mL in ethanol, 97 atom % D, 96% (CP)
740543 1α,25-Dihydroxyvitamin D3 (6,19,19-d3) solution, 50 μg/mL in ethanol, 97 atom % D, 96% (CP)
740551 1α,25-Dihydroxyvitamin D3 (6,19,19-d3) solution, 5 μg/mL in ethanol, 97 atom % D, 96% (CP)
42579 4-Phenyl-1,2,4-triazoline-3,5-dione, for HPLC derivatization, ≥98.0% (CHN)
92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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