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D1756 Sigma

Dexamethasone

≥98% (HPLC), powder

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

  • CAS Number 50-02-2

  • Empirical Formula (Hill Notation) C22H29FO5

  • Molecular Weight 392.46

  •  Beilstein Registry Number 2066651

  •  EC Number 200-003-9

  •  MDL number MFCD00064136

  •  PubChem Substance ID 24893536

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
InChI Key   UREBDLICKHMUKA-CXSFZGCWSA-N
assay   ≥98% (HPLC)
form   powder
color   off-white
mp   262-264 °C(lit.)
solubility   ethanol: 1 mg/mL
originator   Merck Sharp & Dohme
  Merck Sharp & Dohme
storage temp.   2-8°C
Gene Information   human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 5 g in glass bottle

25, 100, 500 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Reconstitution

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
TU3980000

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What is Product D1756, Dexamethasone, soluble in?
Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone, dioxane, and slightly soluble in chloroform. Sigma routinely tests the solubility at 50 mg/mL in ethanol with heat, yielding a clear, colorless to faint yellow solution. However, dexamethasone will precipitate out of solution as the temperature returns to room temperature. At 25 mg/mL in methanol or ethanol, a clear colorless solution is obtained without heating.  The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.
What is the solution stability of Product D1756, Dexamethasone?
Aqueous solutions of dexamethasone are stable for at least 30 days at 4°C. A stock solution at a concentration of 1mg/mL in absolute ethanol can be diluted 1:50 with sterile media and stored frozen as working aliquots.
Is Product D1756, Dexamethasone, suitable for cell culture?
This product has not been tested for cell culture. Please consider either Product No. D8893 or D4902, both of which are cell culture tested.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Immunology Research

The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
Keywords: Antibiotics, Antifungals, Antivirals, Apoptosis, Bioactive small molecules, Cell signaling, Diabetes, Diseases, Immunology, Inflammation

Peer-Reviewed Papers
15

References

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