Dexamethasone

Papers

Identification of Cancer Stem Cells in Ewing's Sarcoma Suv, M., et al. Cancer Res. 69, 1776-81, (2009)

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The Dexamethasone-induced Inhibition Of Proliferation, Migration, And Invasion In Glioma Cell Lines Is Antagonized By Macrophage Migration Inhibitory Factor (MIF) And Can Be Enhanced By Specific MIF Inhibitors. Piette, C., et al. J. Thorac. Cardiovasc. Surg. 284, 32483-92, (2009)

Sumoylation Controls Retinal Progenitor Proliferation By Repressing Cell Cycle Exit In Xenopus Laevis. Terada, K., and Furukawa, T. Dev. Biol. 347, 180-94, (2010)

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Gibberellins Control Fruit Patterning In Arabidopsis Thaliana. Arnaud, N., et al. Genes Dev. 24, 2127-32, (2010)

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Cartilage Tissue Engineering Using Electrospun PCL Nanofiber Meshes And MSCs. Alves da Silva, M.L., et al. Biomacromolecules 11, 3228-36, (2010)

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The Effect Of Mesenchymal Stromal Cells On The Osseoinduction Of Impaction Grafts. Korda, M., et al. Tissue Eng. Part A 16, 675-83, (2010)

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Controlled Release Of Dexamethasone From Subcutaneously-implanted Biosensors In Pigs: Localized Anti-inflammatory Benefit Without Systemic Effects. Ward, W.K., et al. J. Biomed. Mater. Res. A 94, 280-7, (2010)

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The Nup358-RanGAP complex is required for efficient importin α/β-dependent nuclear import. Saskia Hutten et al Mol. Biol. Cell 19, 2300-10, (2008)

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Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Venkata Lokesh Battula et al Haematologica 94, 173-84, (2009)

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The α-subunit of the heterotrimeric G-protein affects jasmonate responses in Arabidopsis thaliana. Haruko Okamoto et al J. Exp. Bot. 60, 1991-2003, (2009)

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Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Mehdi Shakibaei et al J. Biol. Chem. 286, 11492-505, (2011)

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T-typeCa²⁺ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes. Laurent Ferron et al Cardiovasc. Res. 90, 105-12, (2011)

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The research on the immuno-modulatory defect of mesenchymal stem cell from Chronic Myeloid Leukemia patients. Zhu Xishan et al J. Exp. Clin. Cancer Res 30, 47, (2011)

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Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response. Ihtzaz Ahmed Malik et al Cell Tissue Res. 344, 299-312, (2011)

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Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death. Peter M. Voorhees et al Br. J. Haematol. 145, 481-90, (2011)

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The critical role of IL-34 in osteoclastogenesis. Zhi Chen et al PLoS ONE 6, e18689, (2011)

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Development of a surface plasmon resonance biosensor for real-time detection of osteogenic differentiation in live mesenchymal stem cells. Yi-Chun Kuo et al PLoS ONE 6, e22382, (2011)

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Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells. Karen Pauwelyn et al PLoS ONE 6, e23096, (2011)

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Dynamic modulation of thymic microRNAs in response to stress. Serkan Belkaya et al PLoS ONE 6, e27580, (2011)

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Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models. Asaf A Qureshi et al Lipids Health Dis. 10, 177, (2011)

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Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" method. Mike Barker et al J. Med. Chem. 48, 4507-10, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Yong-Hua Wang et al Bioorg. Med. Chem. Lett. 15, 4076-84, (2005)

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Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand. Raj Betageri et al Bioorg. Med. Chem. Lett. 15, 4761-9, (2005)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series. Mike Barker et al J. Med. Chem. 49, 4216-31, (2006)

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Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists. John Regan et al J. Med. Chem. 49, 7887-96, (2006)

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Microwave-enhanced nucleophilic fluorination in the synthesis of fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids, potential glucocorticoid receptor-mediated imaging agents. Michael G C Kahn et al Bioorg. Med. Chem. Lett. 16, 3454-8, (2006)

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Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Roland W Bürli et al Bioorg. Med. Chem. Lett. 16, 3713-8, (2006)

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Transformation of steviol-16alpha,17-epoxide by Streptomyces griseus and Cunninghamella bainieri. Shwu-Fen Chang et al J. Nat. Prod. 69, 1450-5, (2006)

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Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor. Shugeng Cao et al J. Nat. Prod. 69, 707-9, (2006)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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Discovery of potent, selective orally active, nonpeptide inhibitors of human mast cell chymase. Greco, M.N., et al. J. Med. Chem. 50, 1727-1730, (2007)

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Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents. Tadashi Honda et al J. Med. Chem. 50, 1731-4, (2007)

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Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression. Maria D Guerrero et al J. Med. Chem. 50, 2176-84, (2007)

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Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis. Olga Bruno et al J. Med. Chem. 50, 3618-26, (2007)

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Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma. Andrew R Hudson et al J. Med. Chem. 50, 4699-709, (2007)

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Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity. Keith Biggadike et al J. Med. Chem. 50, 6519-34, (2007)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. Mary Kaileh et al J. Biol. Chem. 282, 4253-64, (2007)

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α-Methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands Marshall, D. R.; et al. Bioorg. Med. Chem. Lett. 17, 315, (2007)

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Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: a new use of silicon bioisosteres in medicinal chemistry. Matthew J Barnes et al Bioorg. Med. Chem. Lett. 17, 354-7, (2007)

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Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics. Margaret Clackers et al Bioorg. Med. Chem. Lett. 17, 4737-45, (2007)

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Identification of dissociated non-steroidal glucocorticoid receptor agonists. Daniel Kuzmich et al Bioorg. Med. Chem. Lett. 17, 5025-31, (2007)

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Core exploration in optimization of chemokine receptor CCR4 antagonists. Ashok V Purandare et al Bioorg. Med. Chem. Lett. 17, 679-82, (2007)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity. Javier A Ramírez et al Bioorg. Med. Chem. 15, 7538-44, (2007)

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Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Jeffrey N Miner et al Proc. Natl. Acad. Sci. U. S. A. 104, 19244-9, (2007)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. Huaqing Liu et al J. Med. Chem. 51, 7094-8, (2008)

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High-throughput evaluation of relative cell permeability between peptoids and peptides. Niclas C Tan et al Bioorg. Med. Chem. 16, 5853-61, (2008)

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Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors. Sandip B Bharate et al Bioorg. Med. Chem. 16, 7167-76, (2008)

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Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold. Maurizio Aquino et al Bioorg. Med. Chem. 16, 9056-64, (2008)

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2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. P X Franklin et al Eur. J. Med. Chem. 43, 129-34, (2008)

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Alkaloids from the Australian rainforest tree Ochrosia moorei. Anthony R Carroll et al J. Nat. Prod. 71, 1063-5, (2008)

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Microbial transformation of isosteviol and bioactivities against the glucocorticoid/androgen response elements. Shwu-Fen Chang et al J. Nat. Prod. 71, 87-92, (2008)

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Integrating high-content screening and ligand-target prediction to identify mechanism of action. Daniel W Young et al Nat. Chem. Biol. 4, 59-68, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors. Concettina La Motta et al J. Med. Chem. 52, 1681-92, (2009)

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Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium. Wendy K Strangman et al J. Med. Chem. 52, 2317-27, (2009)

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Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors. David J Fox et al J. Med. Chem. 52, 3591-5, (2009)

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Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides. Bo Liu et al J. Med. Chem. 52, 4604-12, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. Cindy L H Yang et al J. Med. Chem. 52, 6707-15, (2009)

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Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Tsutomu Akama et al Bioorg. Med. Chem. Lett. 19, 2129-32, (2009)

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Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bingwei V Yang et al Bioorg. Med. Chem. Lett. 19, 2139-43, (2009)

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Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Yosuke Nishizaki et al Bioorg. Med. Chem. Lett. 19, 4706-10, (2009)

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Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists. Keith Biggadike et al Bioorg. Med. Chem. Lett. 19, 4846-50, (2009)

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1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors. Olga Bruno et al Bioorg. Med. Chem. 17, 3379-87, (2009)

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6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis. Sara Cesarini et al Bioorg. Med. Chem. 17, 3580-7, (2009)

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Microbial transformation of isosteviol oxime and the inhibitory effects on NF-kappaB and AP-1 activation in LPS-stimulated macrophages. Shwu-Fen Chang et al Bioorg. Med. Chem. 17, 6348-53, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 17, 8168-73, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. Patrick Bydal et al Eur. J. Med. Chem. 44, 632-44, (2009)

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The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. Deborah M Roll et al J. Nat. Prod. 72, 1944-8, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators. Hai-Yun Xiao et al J. Med. Chem. 53, 1270-80, (2010)

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Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. Gang Li et al J. Med. Chem. 53, 1741-54, (2010)

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Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. Valeria Onnis et al J. Med. Chem. 53, 3065-74, (2010)

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Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget. Hai-Bing Zhou et al J. Med. Chem. 53, 3349-60, (2010)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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Structure Guided Design of 5-Arylindazole Glucocorticoid Receptor Agonists and Antagonists C. M. Yates, et al. J. Med. Chem. 53, 4531-4544, (2010)

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Identification and characterization of acidic mammalian chitinase inhibitors. Derek C Cole et al J. Med. Chem. 53, 6122-8, (2010)

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Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics. Doris Riether et al J. Med. Chem. 53, 6681-98, (2010)

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Synthesis and biochemical characterization of a series of 17?-perfluoroalkylated estradiols as selective ligands for estrogen receptor ?. Barbara Eignerová et al J. Med. Chem. 53, 6947-53, (2010)

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Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. Yong-Kang Zhang et al Bioorg. Med. Chem. Lett. 20, 2270-4, (2010)

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Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity. Babasaheb P Bandgar et al Bioorg. Med. Chem. Lett. 20, 2292-6, (2010)

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5-Functionalized indazoles as glucocorticoid receptor agonists. Mei Bai et al Bioorg. Med. Chem. Lett. 20, 3017-20, (2010)

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Discovery of quinolines as selective glucocorticoid receptor agonists. Stefan Jaroch et al Bioorg. Med. Chem. Lett. 20, 5835-8, (2010)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 18, 1364-70, (2010)

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Synthesis and biological screening of a combinatorial library of beta-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 18, 2060-5, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production. Chien-Shu Chen et al Bioorg. Med. Chem. 18, 597-604, (2010)

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Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. 18, 6149-55, (2010)

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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity. Babasaheb P Bandgar et al Eur. J. Med. Chem. 45, 2629-33, (2010)

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Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents. Babasaheb P Bandgar et al Eur. J. Med. Chem. 45, 3223-7, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo. Teresa Krakauer et al Antimicrob. Agents Chemother. 54, 1125-31, (2010)

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Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Robert Bucki et al Antimicrob. Agents Chemother. 54, 2525-33, (2010)

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Activity of physalin F in a collagen-induced arthritis model. Daniele Brustolim et al J. Nat. Prod. 73, 1323-6, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents. Tadashi Honda et al J. Med. Chem. 54, 1762-78, (2011)

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Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms. Jean Leandro dos Santos et al J. Med. Chem. 54, 5811-9, (2011)

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Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases Crosignani, S.; et al. J. Med. Chem. 20th ed., 54, 7299-7317, (2011)

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Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide and Its Methylene Homologue Weinstein, D. S.; et al. J. Med. Chem. 54, 7318-7333, (2011)

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Discovery of a potent series of non-steroidal non ?-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity. Hawa Diallo et al Bioorg. Med. Chem. Lett. 21, 1126-33, (2011)

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Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs). Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 1744-7, (2011)

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A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-? in activated RAW 264.7 cells. Nguyen Xuan Nhiem et al Bioorg. Med. Chem. Lett. 21, 1777-81, (2011)

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The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. Rajesh H Tale et al Bioorg. Med. Chem. Lett. 21, 4648-51, (2011)

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Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives. Salvatore Genovese et al Bioorg. Med. Chem. Lett. 21, 5995-8, (2011)

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Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties. Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 6310-3, (2011)

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Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores. Raj Betageri et al Bioorg. Med. Chem. Lett. 21, 6842-51, (2011)

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Chisopanins A-K, 11 new protolimonoids from Chisocheton paniculatus and their anti-inflammatory activities. Ming-Hua Yang et al Bioorg. Med. Chem. 19, 1409-17, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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Effects of ?-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Liuqiang Zhang et al Bioorg. Med. Chem. 19, 4882-6, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Potential anti-inflammatory constituents of the stems of Gordonia chrysandra. Hui-Zheng Fu et al J. Nat. Prod. 74, 1066-72, (2011)

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Phenolic substances from Phagnalon rupestre protect against 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity. Elisa Giner et al J. Nat. Prod. 74, 1079-84, (2011)

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Lignans and neolignans from Sinocalamus affinis and their absolute configurations. Liang Xiong et al J. Nat. Prod. 74, 1188-200, (2011)

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Transformation of isosteviol lactam by fungi and the suppressive effects of its transformed products on LPS-induced iNOS expression in macrophages. Bo-Hon Chou et al J. Nat. Prod. 74, 1379-85, (2011)

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Antinociceptive properties of bergenin. Cristiane Metzker de Oliveira et al J. Nat. Prod. 74, 2062-8, (2011)

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Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III. Tae-Hee Kang et al J. Nat. Prod. 74, 223-7, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. Zhang Y Lipids Health Dis. 10, 122, (2011)

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Mesenchymal stem cells improve wound healing in vivo via early activation of matrix metalloproteinase-9 and vascular endothelial growth factor. Kim CH J. Korean Med. Sci. 26(6), 726-33, (2011)

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Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Riccardi, C., et al. Cell Death Differ. 6, 1182-1189, (1999)

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Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms. Wershil, B.K., et al. Int. Arch. Allergy Immunol. 107, 323-324, (1995)

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Effect of dexamethasone on nitric oxide (NO) production by cultured astrocytes. Llanos, S.L., and Roldan, A. Biocell 23, 29-35, (1999)

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Merck 14,2943

Aldrich MSDS 1, 556:D / Corp MSDS 1 (1), 1039:B / FT-NMR 1 (3), 585:C / RegBook 1 (2), 2863:L / Sax 6, 2493 / Sigma FT-IR 1 (1), 1233:A / Structure Index 1, 458:A:8