EMAIL THIS PAGE TO A FRIEND
D2043 Sigma

Defensin HNP-1 human

≥80% (HPLC)

Synonym: Neutrophil Peptide-1

  • CAS Number 99287-08-8

  • Empirical Formula (Hill Notation) C150H222N44O38S6

  • Molecular Weight 3442.03

  •  MDL number MFCD00214572

  •  PubChem Substance ID 329798727

Purchase

Properties

Related Categories A - K, Antibacterial, Antibiotic Peptides, Antibiotics, Antibiotics A to Z,
InChI Key   KRJOFJHOZZPBKI-KSWODRSDSA-N
assay   ≥80% (HPLC)
composition   Peptide content, ~70%
solubility   water: soluble1 mg/mL, clear, colorless
Mode of action   cell membrane | interferes
antibiotic activity spectrum   fungi
  mycobacteria
  viruses
storage temp.   −20°C
Gene Information   human ... DEFA1(1667)

Description

Amino Acid Sequence

Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys [Disulfide bridges: 2−30; 4−19; 9−29]

Biochem/physiol Actions

This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this family are variably arginine-rich and share six conserved cysteine residues that participate in intramolecular disulfide bonds.

Price and Availability


Amplified Detection

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?