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D2154 Sigma

5,6-Dehydroarachidonic acid

≥98%, ethanol solution

Synonym: 5,6-dehydro AA, cis-8,11,14-Eicosatrien-5-ynoic acid

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Description

Biochem/physiol Actions

Inhibits 5-lipoxygenase of guinea pig leukocytes with an IC50 of 10 μM. In extracts of rat basophilic leukemia cells preincubated with 5,6-dehydro AA, the Ki for the conversion of arachidonic acid to 5-HPETE is 15 μM.

General description

An analog of arachidonic acid in which the 5,6 double bond has been replaced with an acetylene group.

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Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany 
2
Flash Point(F) 
62.6 °F
Flash Point(C) 
17 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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