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D2178 Sigma

Monoclonal Anti-Death Associated Protein Kinase antibody produced in mouse

clone DAPK-55, ascites fluid

Synonym: Anti-DAP Kinase

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Other Apoptosis-related Proteins,
species reactivity   monkey, human
application(s)   immunoprecipitation: suitable
  microarray: suitable
  western blot: 1:250 using COS-7 cell extract
clone   DAPK-55, monoclonal
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt 160 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... DAP(1611)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human DAP kinase expressed in bacteria.

General description

The gene is widely expressed in many tissues of embryonic and adult origin and gives rise to a single 6.3 Kb mRNA transcript. The protein consists of 1423 amino acids (160 kDa) and belongs to a family of calmodulin-dependent protein kinases. It contains 8 ankyrin repeats and 2 potential P-loop motifs apart from the kinase domain and the calmodulin regulatory domain.

Application

Monoclonal Anti-Death Associated Protein Kinase antibody produced in mouse is suitable for immunoprecipitation, microarray and western blotting at a working dilution of 1:250 using COS-7 cell extract. It may be used for the detection and quantification of kinase activity of DAP Kinase using various immunochemical assays such as immunoblot and immunoprecipitation.

Features and Benefits

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Biochem/physiol Actions

DAP-kinase is a novel, structurally unique, human serine/threonine kinase identified as a positive mediator of interferon-γ-induced programmed cell death. It has an intrinsic kinase activity towards itself that is regulated by calmodulin and calcium.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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D4941 Monoclonal Anti-phospho-DAP-Kinase (pSer308) antibody produced in mouse, clone DKPS308, purified immunoglobulin, buffered aqueous solution
D1319 Anti-DAP Kinase 1 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

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