Difloxacin hydrochloride
DOWNLOAD MSDS (PDF)Synonym:
6-
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CAS Number 91296-86-5
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Empirical Formula (Hill Notation) C21H19F2N3O3 · HCl
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Molecular Weight 435.85
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MDL number MFCD03840489
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Popular Documents: Specification Sheet (PDF)
Properties
| Related Categories | A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, |
| assay | ≥98% (HPLC) |
| storage temp. | room temp |
Description
Biochem/physiol Actions
Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription
Fluoroquinolone antibacterial compound. Structurally related to norfloxacin.
Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin.
Mode of Action: A ds-DNA binding DNA gyrase inhibitor to dysrupt DNA synthesis. Use to study the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage.
Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa.1 Active against gram-positive bacteria and excellent activity against gram-negative bacteria.2
Application
Difloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. It is a potential treatment for Chlamydia trachomatis infections1 and chronic Q fever in humans2. It has been used to study how potential supplementation (magnesium) may reduce quinolone-induced damage in the horse and dog models3.
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