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D2915 Sigma

Dexamethasone-Water Soluble

suitable for cell culture, BioReagent

Synonym: Dexamethasone – Cyclodextrin complex

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Hormones, Immune Cell Signaling and Blood,
InChI Key   XEJNDGTUKUMQNG-ARJMFYCQSA-N
product line   BioReagent
solubility   H2O: 25 mg/mL clear to slightly hazy
suitability   suitable for cell culture

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

An anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. Use to study apoptosis, cell signaling pathways and gene expression.

Other Notes

Contains approx. 65 mg dexamethasone per gram; balance methyl-β-cyclodextrin.

Packaging

100 mg in glass bottle

Package size based on dexamethasone

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
TU3980000

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

What cell lines has Product D4902, Dexamethasone, been tested on?
The cell lines on which this product is tested can vary from lot to lot. Some typically used cell lines are 3T3 fibroblasts, BHK, L929 and CHO.
Are Products D4902 and D2915, sterile?
No. This product is not sterile, but cell culture testing did not find the product to be toxic to cells.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How long is Product D2915, Dexamethasone-Water Soluble, stable in solution?
Dexamethasone solutions are stable for 6 months when aliquoted stored at -20 °C in a non-defrosting freezer and protected from light.  However, insufficient information is available to assess the shelf-life of solutions stored at 4°C.
What is the molecular weight of Product D2915, Dexamethasone-Water Soluble?
The molecular weight of dexamethasone alone is 392.5 g/mol. Be sure to take the weight of the carrier into account for any calculations involving molarity of solutions.
How much Product D2915, Dexamethasone-Water Soluble, have I received?
Each vial contains 100mg of Dexamethasone.  The milligrams of Dexamethasone per gram (Dexamethasone content) is listed on the Certificate of Analysis, which can be accessed through our Advanced Search Option by clicking on the following link: http://www.sigmaaldrich.com/catalog/search/AdvancedSearchPage  This information can be used to determine the conversion factor to make a solution of a given molarity.
Can I use Product D2915, Dexamethasone-Water Soluble, to inject into mice?
We do not perform animal studies with our products, but it can be used in cell culture.
How should I reconstitute Product D2915, Dexamethasone-Water Soluble, for tissue culture use?
The tissue culture grade product is tested in water at a concentration of 25 mg/mL forming a clear to slightly hazy colorless solution.
Do you have references for the use of Product D2915, Dexamethason - Water Soluble?
Here is one reference that describes using Product No. D2915: Chang, C.-J., et al., Coactivator TIF1β Interacts with Transcription Factor C/EBPβ and Glucocorticoid Receptor To Induce α1-Acid Glycoprotein Gene Expression. Mol. Cell. Biol., 18(10), 5880-5887 (1998).
What is (2-Hydroxypropyl)-ß-cyclodextrin contained in Product D2915?
(2-Hydroxypropyl)-ß-cyclodextrin is commonly used to get lipophilic drugs into aqueous solutions. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility.
Is the (2-Hydroxypropyl)-ß-cyclodextrin contained in Product D2915, Dexammethasone - Water Soluble, toxic to cells?
The carrier, (2-Hydroxypropyl)-ß-cyclodextrin, has been found to be non-toxic to mice and rabbits.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
Can Product D2915, Dexamethasone - Water Soluble, be filter sterilized?
This product can be filter sterilized through a 0.22 micron filter prior to use.
  What kind of solution is the A5955 - Antibiotic Antimycotic Solution (100×), Stabilized product suspended in?
A5955 - Antibiotic Antimycotic Solution (100×), Stabilized is supsended in a sodium citrate buffer solution. Source: Israel production group
Show more questions
Protocols & Articles
Peer-Reviewed Papers
15

References

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C0926 (2-Hydroxypropyl)-β-cyclodextrin, powder, BioReagent, suitable for cell culture

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