|Related Categories||Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F, Glycobiology,|
|impurities||≤0.001% Phosphorus (P)|
|<0.1% Insoluble matter|
|solubility||H2O: soluble1 M at 20 °C, clear, colorless|
|anion traces||chloride (Cl-): ≤0.05%|
|sulfate (SO42-): ≤0.05%|
|cation traces||Al: ≤0.0005%|
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy. Kalia VK, Prabhakara S, Narayanan V. J. Cancer Res. Ther. 5, S57-60, (2009)
A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction. Bhardwaj R, Sharma PK, Jadon SS, Varshney R. Tumour Biol. 32, 951-964, (2011)
FT-IR 2 (1), 276:B / FT-IR 1 (1), 192:D / FT-NMR 1 (1), 296:B / IR-Spectra (2), 108:B / IR-Spectra (3), 116:F / NMR-Reference 2 (2), 909:B / RegBook 1 (1), 191:G / Sax 6, 867 / Sigma FT-IR 1 (1), 1054:B / Structure Index 1, 26:D:1
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