2-Deoxy-D -glucose
BioXtra, ≥98%
DOWNLOAD MSDS (PDF)Synonym:
2-Deoxy-
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CAS Number 154-17-6
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Empirical Formula (Hill Notation) C6H12O5
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Molecular Weight 164.16
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Beilstein Registry Number 1723331
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EC Number 205-823-0
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MDL number MFCD00151328
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PubChem Substance ID 24893732
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Popular Documents: FTNMR (PDF)
Properties
| Related Categories | Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F, Glycobiology, |
| product line | BioXtra |
| assay | ≥98% |
| impurities | ≤0.001% Phosphorus (P) |
| <0.1% Insoluble matter | |
| ign. residue | <0.1% |
| mp | 146-147 °C(lit.) |
| solubility | H2O: soluble1 M at 20 °C, clear, colorless |
Description
Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
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