|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, DIG-DY,|
|solubility||DMSO: soluble25 mg/mL (warm)|
|ethanol: soluble25 mg/mL (warm)|
Biosynthetic precursor to sphingosine; inhibits protein kinase C.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D3314.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). Merrill, Jr., A.H., and Wang, E. J. Biol. Chem. 261, 3764, (1986)
Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. Meyer SG, Wendt AE, Scherer M, et al. Arch. Biochem. Biophys. 526(1), 60-8, (2012)
Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. Fischer CL, Drake DR, Dawson DV, et al. Antimicrob. Agents Chemother. 56(3), 1157-61, (2012)
Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors. Murakami I, Wakasa Y, Yamashita S, et al. Lipids Health Dis. 10, 150, (2011)
Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. Cano-Sancho G, Marin S, Sanchis V, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 28(8), 1055-65, (2011)
Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. Gelineau-van Waes J, Rainey MA, Maddox JR, et al. Birth Defects Res. A Clin. Mol. Teratol. 94(10), 790-803, (2012)
Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. Knapp M, Zendzian-Piotrowska M, Błachnio-Zabielska A, et al. Basic Res. Cardiol. 107(6), 294, (2012)
Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Sun Y, Miao Y, Yamane Y, et al. Mol. Biol. Cell 23(12), 2388-98, (2012)
Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. Vandenbosch D, Bink A, Govaert G, et al. Antimicrob. Agents Chemother. 56(5), 2290-4, (2012)
MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. Saucedo-García M, Guevara-García A, González-Solís A, et al. New Phytol. 191(4), 943-57, (2011)
Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. Roviezzo F, Brancaleone V, De Gruttola L, et al. J. Pharmacol. Exp. Ther. 337(3), 830-7, (2011)
Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro. Zimber A, Chedeville A, Gespach C, et al. Int. J. Cancer 59(1), 71-7, (1994)
Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry. Yang YJ, Lee J, Choi MH, et al. Biomed. Chromatogr. 17(4), 219-25, (2003)
Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. Bouchon B, Portoukalian J, Orgiazzi J, et al. Biochem. Biophys. Res. Commun. 143(3), 827-31, (1987)
Estriol and its conjugates in late pregnancy determined by extraction with Carbopack B and liquid chromatography with fluorometric detection. Andreolini F, Borra C, Caccamo F, et al. Clin. Chem. 31(10), 1698-702, (1985)
Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. Rodriguez-Lafrasse C, Rousson R, Pentchev PG, et al. Biochim. Biophys. Acta 1226(2), 138-44, (1994)
High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia. Ribar S, Mesarić M, and Bauman M J. Chromatogr. B. Biomed. Sci. Appl. 754(2), 511-9, (2001)
Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. van der Westhuizen L, Brown NL, Marasas WF, et al. Food Chem. Toxicol. 37(12), 1153-8, (1999)
In vivo distribution of free long-chain sphingoid bases in the human stratum corneum by high-performance liquid chromatographic analysis of strippings. Flamand N, Justine P, Bernaud F, et al. J. Chromatogr. B, Biomed. Appl. 656(1), 65-71, (1994)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?