Synonym: Cupral, Diethyldithiocarbamic acid sodium salt
|Related Categories||Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,|
|vapor density||5.9 (vs air)|
|storage temp.||room temp|
Inhibits induction of macrophage nitric oxide synthase.
May form insoluble oxidation products in storage. Sensitivity in colorimetric copper determination not usually affected.
Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.
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ACS reagent, for the determination and separation of heavy metals, ≥99.0%
PESTANAL®, analytical standard
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|Precautionary statements||P280-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-38-41|
|Safety Statements (Europe)||26-39|
Phenylalanine is an essential amino acid that is converted to tyrosine primarily in the liver by phenylalanine hydroxylase. Blood borne tyrosine, derived from dietary proteins and from phenylalanine ...
Keywords: Catalysis, Enzyme activity, Hydroxylations, Metabolism, Phosphorylations
DFT: B3LYP/6-311G (d, p) vibrational analysis of bis-(diethyldithiocarbamate)zinc(II) and natural bond orbitals. Costa AC, Ondar GF, Versiane O, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 105, 251-8, (2013)
New insight into hyperthermic intraperitoneal chemotherapy: induction of oxidative stress dramatically enhanced tumor killing in in vitro and in vivo models. Lehmann K, Rickenbacher A, Jang JH, et al. Ann. Surg. 256(5), 730-7; discussion 737-8, (2012)
Comparative study of the quercetin, ascorbic acid, glutathione and superoxide dismutase for nitric oxide protecting effects in mouse gastric fundus. Ertuğ PU, Aydinoglu F, Goruroglu Ozturk O, et al. Eur. J. Pharmacol. 698(1-3), 379-87, (2013)
Electrophilic adduction of ubiquitin activating enzyme E1 by N,N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat. Viquez OM, Caito SW, McDonald WH, et al. Chem. Res. Toxicol. 25(11), 2310-21, (2012)
The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis. Rahden-Staroń I, Grosicka-Maciąg E, Kurpios-Piec D, et al. Arch. Toxicol. 86(12), 1841-50, (2012)
Effect of inhibition of superoxide dismutase on motor neurons during growth: comparison of phosphorylated and non-phosphorylated neurofilament-containing spinal neurons by histogram distribution. Isonaka R, Katakura T, and Kawakami T Brain Res. 1470, 11-6, (2012)
Hydrogen sulfide mediates hypoxic vasoconstriction through a production of mitochondrial ROS in trout gills. Skovgaard N and Olson KR Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(5), R487-94, (2012)
Solidified floating organic drop microextraction combined with ETV-ICP-MS for the determination of trace heavy metals in environmental water samples. Guo X, He M, Chen B, et al. Talanta 94, 70-6, (2012)
Enhancement of μ-opioid receptor desensitization by nitric oxide in rat locus coeruleus neurons: involvement of reactive oxygen species. Llorente J, Santamarta MT, Henderson G, et al. J. Pharmacol. Exp. Ther. 342(2), 552-60, (2012)
Determination of Pb(II), Zn(II), Cd(II), and Co(II) ions by flame atomic absorption spectrometry in food and water samples after preconcentration by coprecipitation with Mo(VI)-diethyldithiocarbamate. Tufekci M, Bulut VN, Elvan H, et al. Environ. Monit. Assess. 185(2), 1107-15, (2013)
Synergistic enhancement effect of room temperature ionic liquids for cloud point extraction combined with UV-vis spectrophotometric determination nickel in environmental samples. Zeng C, Xu X, Zhou N, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 94, 48-52, (2012)
The use of thallium diethyldithiocarbamate for mapping CNS potassium metabolism and neuronal activity: Tl+ -redistribution, Tl+ -kinetics and Tl+ -equilibrium distribution. Wanger T, Scheich H, Ohl FW, et al. J. Neurochem. 122(1), 106-14, (2012)
Fourier Transform Infrared and Raman spectra, DFT: B3LYP/6-311G(d, p) calculations and structural properties of bis(diethyldithiocarbamate)copper(II). Costa AC, Ramos JM, Téllez Soto CA, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 105, 259-66, (2013)
Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates. Horita Y, Takii T, Yagi T, et al. Antimicrob. Agents Chemother. 56(8), 4140-5, (2012)
Effects of the fungicide metiram in outdoor freshwater microcosms: responses of invertebrates, primary producers and microbes. Lin R, Buijse L, Dimitrov MR, et al. Ecotoxicology 21(5), 1550-69, (2012)
Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats. Sharma B and Singh N Psychopharmacology 223(3), 307-17, (2012)
Displacement-dispersive liquid-liquid microextraction based on solidification of floating organic drop of trace amounts of palladium in water and road dust samples prior to graphite furnace atomic absorption spectrometry determination. Ghanbarian M, Afzali D, Mostafavi A, et al. J. AOAC Int. 96(4), 880-6, (2013)
Diethyldithiocarbamate induces apoptosis in neuroblastoma cells by raising the intracellular copper level, triggering cytochrome c release and caspase activation. Matias AC, Manieri TM, Cipriano SS, et al. Toxicol. In Vitro 27(1), 349-57, (2013)
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