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D3688 Sigma

Anti-DR3, Extracellular Domain antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Apo-3, Anti-Death Receptor 3, Anti-LARD, Anti-TRAMP, Anti-Wsl-1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Death Receptors,
species reactivity   human
application(s)   western blot: 0.5 μg/mL using human Jurkat cell extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 59 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... TNFRSF25(8718)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 59-77 of the extracellular domain of human DR3 precursor.

General description

DR3 is a member of the TNF superfamily. It is expressed in lymphocyte rich tissues such as blood, thymus and spleen.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Application

Anti-DR3 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 0.5μg/mL using total cell lysates from Jurkat cells. It was used as a primary antibody in immunoblotting analysis of adenocarcinoma cells to examine 14-3-3 isoforms expressed in normal and cancerous lung tissues.

Features and Benefits

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Biochem/physiol Actions

DR3 is a death domain-containing receptor that is involved in inducing apoptosis or programmed cell death in cells. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases, which cause the degradation of chromosomal DNA by activating DNase. It also activates NF-κB, a protein complex that controls transcription of DNA.

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Safety Information

WGK Germany  3
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Peer-Reviewed Papers
15

References

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