• USA Home
  • D3775 - Doxylamine succinate salt

EMAIL THIS PAGE TO A FRIEND
D3775 Sigma

Doxylamine succinate salt

Purchase

Description

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.
Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.
Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Packaging

5, 50 g in glass bottle

Application

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Doxylamine belongs to the ethanolaime class of antihistamines and is metabolised by the liver into N-demethyl doxylamine and N,N-didemethyl doxylamine. It is generally available as an over the counter (OTC) drug for allergy and cold symptoms.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


DISCOVER Bioactive Small Molecules

Making Headway

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
US9275000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Related Content

Carcinogen Selector - Digestive System - Liver

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System - Liver
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Liver Endocrine

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Liver Endocrine
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Thyroid Gland

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Thyroid Gland
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?